TY - JOUR
T1 - The role of laquinimod in modulation of the immune response in relapsing-remitting multiple sclerosis
T2 - Lessons from gene expression signatures
AU - Zilkha-Falb, R.
AU - Gurevich, M.
AU - Hayardeny, L.
AU - Achiron, A.
N1 - Publisher Copyright:
© 2015 Elsevier B.V.
PY - 2015/6/15
Y1 - 2015/6/15
N2 - Laquinimod, is a potential oral immunomodulatory drug, for relapsing-remitting multiple sclerosis (RRMS).We analyzed the blood-transcriptional changes in RRMS patients (who participated in the ALLEGRO clinical trial) at one and six months after laquinimod treatment using gene expression microarrays.The molecular effects of laquinimod were enhanced by duration of treatment and showed down-regulation of inflammatory responses mainly via TGFb signaling, and of pro-inflammatory cytokines as well as of cellular movement, including adhesion, migration and leukocyte extravasation signaling.Our results demonstrate that laquinimod suppresses inflammation through down-regulation of inflammatory cytokines and arrest of leukocyte extravasation and thereby could attenuate disease activity in RRMS patients.
AB - Laquinimod, is a potential oral immunomodulatory drug, for relapsing-remitting multiple sclerosis (RRMS).We analyzed the blood-transcriptional changes in RRMS patients (who participated in the ALLEGRO clinical trial) at one and six months after laquinimod treatment using gene expression microarrays.The molecular effects of laquinimod were enhanced by duration of treatment and showed down-regulation of inflammatory responses mainly via TGFb signaling, and of pro-inflammatory cytokines as well as of cellular movement, including adhesion, migration and leukocyte extravasation signaling.Our results demonstrate that laquinimod suppresses inflammation through down-regulation of inflammatory cytokines and arrest of leukocyte extravasation and thereby could attenuate disease activity in RRMS patients.
KW - Gene expression microarray
KW - Laquinimod
KW - Multiple sclerosis
KW - Peripheral blood mononuclear cells
UR - http://www.scopus.com/inward/record.url?scp=84929598546&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2015.04.007
DO - 10.1016/j.jneuroim.2015.04.007
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C2 - 26004150
AN - SCOPUS:84929598546
VL - 283
SP - 11
EP - 16
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
ER -