TY - JOUR
T1 - The role of IVIg treatment in severe pemphigus vulgaris
AU - Baum, S.
AU - Scope, A.
AU - Barzilai, A.
AU - Azizi, E.
AU - Trau, H.
PY - 2006/5
Y1 - 2006/5
N2 - Background: High-dose intravenous immunoglobulin (IVIg) has become a part of the treatment armentarium in pemphigus vulgaris (PV). Some consider IVIg as an adjuvant steroid sparing agent in PV, while others as disease modifying that can be used as monotherapy. Methods: We report our experience with a series of 12 PV patients with severe disease treated with IVIg as an adjuvant therapy. Results: Ten of 12 patients (83%) showed response to six cycles of IVIg, six (50%) having complete remission and four (33%) having a partial response. This response rate is concordant with previous reports. The therapy was well tolerated. In all 12 patients, treatment with IVIg allowed a gradual reduction of prednisone dose compared with baseline levels. Conclusion: IVIg treatment was beneficial as asteroid sparing agent in our series of patients with severe PV.
AB - Background: High-dose intravenous immunoglobulin (IVIg) has become a part of the treatment armentarium in pemphigus vulgaris (PV). Some consider IVIg as an adjuvant steroid sparing agent in PV, while others as disease modifying that can be used as monotherapy. Methods: We report our experience with a series of 12 PV patients with severe disease treated with IVIg as an adjuvant therapy. Results: Ten of 12 patients (83%) showed response to six cycles of IVIg, six (50%) having complete remission and four (33%) having a partial response. This response rate is concordant with previous reports. The therapy was well tolerated. In all 12 patients, treatment with IVIg allowed a gradual reduction of prednisone dose compared with baseline levels. Conclusion: IVIg treatment was beneficial as asteroid sparing agent in our series of patients with severe PV.
KW - Intravenous immunoglobulin treatment
KW - Severe pemphigus vulgaris
KW - Steroid sparing treatment
UR - http://www.scopus.com/inward/record.url?scp=33646028768&partnerID=8YFLogxK
U2 - 10.1111/j.1468-3083.2006.01540.x
DO - 10.1111/j.1468-3083.2006.01540.x
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C2 - 16684282
AN - SCOPUS:33646028768
SN - 0926-9959
VL - 20
SP - 548
EP - 552
JO - Journal of the European Academy of Dermatology and Venereology
JF - Journal of the European Academy of Dermatology and Venereology
IS - 5
ER -