The role of intravenous albumin in the prevention of severe ovarian hyperstimulation syndrome: A pilot experimental study

Objective: To evaluate the role of intravenous albumin in the prevention of severe ovarian hyperstimulation syndrome (OHSS). Design: A pilot experimental study. Material and Methods: Ovarian hyperstimulation was induced in 5 rabbits using human menopausal gonadotropin/human chorionic gonadotropin, after pretreatment without (control group) or with bovine serum albumin (BSA group). Results: Despite an increase in serum protein levels, the BSA group showed comparable Δ increase in body weight and degree of ascites formation. Conclusions: Intravenous albumin did not prevent severe OHSS in a rabbit model despite the observed increase in serum oncotic pressure.