The role of glucocorticoids in the treatment of fulminant hepatitis induced by dacarbazine

Yair Herishanu; Michael Lishner; Yona Kitay-Cohen

doi:10.1097/00001813-200202000-00011

The role of glucocorticoids in the treatment of fulminant hepatitis induced by dacarbazine

Yair Herishanu, Michael Lishner, Yona Kitay-Cohen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Dacarbazine (DTIC) is commonly used for the treatment of malignant melanoma and Hodgkin's disease. Avery rare complication of this cytotoxic agent is acute vascular hepatic damage, e.g. veno-occlusive disease or Budd-Chiari syndrome. The pathophysiological mechanism involved seems to be an immune reaction. This complication is frequently fatal. We report a patient who developed severe hepatic failure following DTIC treatment who responded favorably to treatment with glucocorticosteroid. [

Original language	English
Pages (from-to)	177-179
Number of pages	3
Journal	Anti-Cancer Drugs
Volume	13
Issue number	2
DOIs	https://doi.org/10.1097/00001813-200202000-00011
State	Published - 2002
Externally published	Yes

Keywords

Dacarbazine
Fulminant hepatitis
Steroids

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/00001813-200202000-00011

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abstract = "Dacarbazine (DTIC) is commonly used for the treatment of malignant melanoma and Hodgkin's disease. Avery rare complication of this cytotoxic agent is acute vascular hepatic damage, e.g. veno-occlusive disease or Budd-Chiari syndrome. The pathophysiological mechanism involved seems to be an immune reaction. This complication is frequently fatal. We report a patient who developed severe hepatic failure following DTIC treatment who responded favorably to treatment with glucocorticosteroid. [",

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AB - Dacarbazine (DTIC) is commonly used for the treatment of malignant melanoma and Hodgkin's disease. Avery rare complication of this cytotoxic agent is acute vascular hepatic damage, e.g. veno-occlusive disease or Budd-Chiari syndrome. The pathophysiological mechanism involved seems to be an immune reaction. This complication is frequently fatal. We report a patient who developed severe hepatic failure following DTIC treatment who responded favorably to treatment with glucocorticosteroid. [

KW - Dacarbazine

KW - Fulminant hepatitis

KW - Steroids

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The role of glucocorticoids in the treatment of fulminant hepatitis induced by dacarbazine

Abstract

Keywords

UN SDGs

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