TY - JOUR
T1 - The role of Fyn kinase in the release from metaphase in mammalian oocytes
AU - Levi, M.
AU - Shalgi, R.
N1 - Funding Information:
This work was partially supported by a grant from the Israel Science Foundation to R. Shalgi (695/05) and by the Eshkol scholarship by the Israel Ministry of Science, Culture and Sport. We thank prof. Bernared Maro (CNRS, Paris, France) for his valuable advice. We also thank Ruth Kaplan-Kraicer for her help in preparation of the review. This work is a partial fulfillment of the requirements for the Ph.D. degree of Levi M. at the Sackler Faculty of Medicine, Tel-Aviv University.
PY - 2010/1/27
Y1 - 2010/1/27
N2 - Meiosis in mammalian oocytes starts during embryonic life and arrests for the first time before birth, at prophase of the first meiotic division. The second meiotic arrest occurs after spindle formation at metaphase of the second meiotic division (MII) in selected oocytes designated for ovulation. The fertilizing spermatozoon induces the release from MII arrest only after the oocyte's spindle assembly checkpoint (SAC) was deactivated. Src family kinases (SFKs) are nine non-receptor protein tyrosine kinases that regulate many key cellular functions. Fyn is an SFK expressed in many cell types, including oocytes. Recent studies, including ours, imply a role for Fyn in exit from meiotic and mitotic metaphases. Other studies demonstrate that SFKs, particularly Fyn, are required for regulation of microtubules polymerization and spindle stabilization. Altogether, Fyn is suggested to play an essential role in signaling events that implicate SAC pathway and hence in regulating the exit from metaphase in oocytes and zygote.
AB - Meiosis in mammalian oocytes starts during embryonic life and arrests for the first time before birth, at prophase of the first meiotic division. The second meiotic arrest occurs after spindle formation at metaphase of the second meiotic division (MII) in selected oocytes designated for ovulation. The fertilizing spermatozoon induces the release from MII arrest only after the oocyte's spindle assembly checkpoint (SAC) was deactivated. Src family kinases (SFKs) are nine non-receptor protein tyrosine kinases that regulate many key cellular functions. Fyn is an SFK expressed in many cell types, including oocytes. Recent studies, including ours, imply a role for Fyn in exit from meiotic and mitotic metaphases. Other studies demonstrate that SFKs, particularly Fyn, are required for regulation of microtubules polymerization and spindle stabilization. Altogether, Fyn is suggested to play an essential role in signaling events that implicate SAC pathway and hence in regulating the exit from metaphase in oocytes and zygote.
KW - Fyn
KW - Metaphase arrest
KW - Spindle assembly checkpoint (SAC)
KW - Src family kinases (SFKs)
UR - http://www.scopus.com/inward/record.url?scp=71849103122&partnerID=8YFLogxK
U2 - 10.1016/j.mce.2009.08.027
DO - 10.1016/j.mce.2009.08.027
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AN - SCOPUS:71849103122
SN - 0303-7207
VL - 314
SP - 228
EP - 233
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
IS - 2
ER -