TY - JOUR
T1 - The role of fibroblast growth factor 2 in drug addiction
AU - Even-Chen, Oren
AU - Barak, Segev
N1 - Publisher Copyright:
© 2018 Federation of European Neuroscience Societies and John Wiley & Sons Ltd
PY - 2019/8/1
Y1 - 2019/8/1
N2 - Fibroblast growth factor 2 (FGF2) is a member of the FGF-family, which consists of 22 members, with four known FGF receptors (five in humans). Over the last 30 years, FGF2 has been extensively studied for its role in cell proliferation, differentiation, growth, survival and angiogenesis during development, as well as for its role in adult neurogenesis and regenerative plasticity. Over the past decade, FGF2 has been implicated in learning and memory, as well as in several neuropsychiatric disorders, including anxiety, stress, depression and drug addiction. In this review, we present accumulating evidence indicating the involvement of FGF2 in neuroadaptations caused by drugs of abuse, namely, amphetamine, cocaine, nicotine and alcohol. Moreover, evidence suggests that FGF2 is a positive regulator of alcohol and drug-related behaviors. Thus, although additional studies are yet required, we suggest that reducing FGF2 activity may provide a novel therapeutic approach for substance use disorders.
AB - Fibroblast growth factor 2 (FGF2) is a member of the FGF-family, which consists of 22 members, with four known FGF receptors (five in humans). Over the last 30 years, FGF2 has been extensively studied for its role in cell proliferation, differentiation, growth, survival and angiogenesis during development, as well as for its role in adult neurogenesis and regenerative plasticity. Over the past decade, FGF2 has been implicated in learning and memory, as well as in several neuropsychiatric disorders, including anxiety, stress, depression and drug addiction. In this review, we present accumulating evidence indicating the involvement of FGF2 in neuroadaptations caused by drugs of abuse, namely, amphetamine, cocaine, nicotine and alcohol. Moreover, evidence suggests that FGF2 is a positive regulator of alcohol and drug-related behaviors. Thus, although additional studies are yet required, we suggest that reducing FGF2 activity may provide a novel therapeutic approach for substance use disorders.
KW - FGF2
KW - Nicotine
KW - addiction
KW - alcohol
KW - amphetamine
KW - cocaine
UR - http://www.scopus.com/inward/record.url?scp=85053426878&partnerID=8YFLogxK
U2 - 10.1111/ejn.14133
DO - 10.1111/ejn.14133
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AN - SCOPUS:85053426878
SN - 0953-816X
VL - 50
SP - 2552
EP - 2561
JO - European Journal of Neuroscience
JF - European Journal of Neuroscience
IS - 3
ER -