TY - JOUR
T1 - The role of endothelin in coronary atherosclerosis
AU - Mathew, Verghese
AU - Hasdai, David
AU - Lerman, Amir
PY - 1996
Y1 - 1996
N2 - During the evolution of coronary atherosclerosis, growth factors, cytokines, and other molecules are involved in cell recruitment, migration, and proliferation. Endothelin is an endothelial-derived vasoconstrictor peptide that possesses mitogenic properties. In this review, current evidence is provided that suggests that endothelin fulfills proposed criteria to be considered an atherogenic peptide because of its mitogenic and proliferative properties, as well as its inter-actions with known atherogenic factors. In addition, a proposed role of endothelin in the evolution of atherosclerosis is outlined.
AB - During the evolution of coronary atherosclerosis, growth factors, cytokines, and other molecules are involved in cell recruitment, migration, and proliferation. Endothelin is an endothelial-derived vasoconstrictor peptide that possesses mitogenic properties. In this review, current evidence is provided that suggests that endothelin fulfills proposed criteria to be considered an atherogenic peptide because of its mitogenic and proliferative properties, as well as its inter-actions with known atherogenic factors. In addition, a proposed role of endothelin in the evolution of atherosclerosis is outlined.
UR - http://www.scopus.com/inward/record.url?scp=0030317635&partnerID=8YFLogxK
U2 - 10.1016/s0025-6196(11)64842-8
DO - 10.1016/s0025-6196(11)64842-8
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AN - SCOPUS:0030317635
SN - 0025-6196
VL - 71
SP - 769
EP - 777
JO - Mayo Clinic Proceedings
JF - Mayo Clinic Proceedings
IS - 8
ER -
