TY - JOUR
T1 - The role of E3, E4 ubiquitin ligase (UBE4B) in human pathologies
AU - Antoniou, Nikolaos
AU - Lagopati, Nefeli
AU - Balourdas, Dimitrios Ilias
AU - Nikolaou, Michail
AU - Papalampros, Alexandros
AU - Vasileiou, Panagiotis V.S.
AU - Myrianthopoulos, Vassilios
AU - Kotsinas, Athanassios
AU - Shiloh, Yosef
AU - Liontos, Michalis
AU - Gorgoulis, Vassilis G.
N1 - Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2020/1
Y1 - 2020/1
N2 - The genome is exposed daily to many deleterious factors. Ubiquitination is a mechanism that regulates several crucial cellular functions, allowing cells to react upon various stimuli in order to preserve their homeostasis. Ubiquitin ligases act as specific regulators and actively participate among others in the DNA damage response (DDR) network. UBE4B is a newly identified member of E3 ubiquitin ligases that appears to be overexpressed in several human neoplasms. The aim of this review is to provide insights into the role of UBE4B ubiquitin ligase in DDR and its association with p53 expression, shedding light particularly on the molecular mechanisms of carcinogenesis.
AB - The genome is exposed daily to many deleterious factors. Ubiquitination is a mechanism that regulates several crucial cellular functions, allowing cells to react upon various stimuli in order to preserve their homeostasis. Ubiquitin ligases act as specific regulators and actively participate among others in the DNA damage response (DDR) network. UBE4B is a newly identified member of E3 ubiquitin ligases that appears to be overexpressed in several human neoplasms. The aim of this review is to provide insights into the role of UBE4B ubiquitin ligase in DDR and its association with p53 expression, shedding light particularly on the molecular mechanisms of carcinogenesis.
KW - Cancer disease
KW - DNA damage response
KW - P53
KW - UBE4B
KW - Ubiquitin ligases
UR - http://www.scopus.com/inward/record.url?scp=85077342008&partnerID=8YFLogxK
U2 - 10.3390/cancers12010062
DO - 10.3390/cancers12010062
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C2 - 31878315
AN - SCOPUS:85077342008
SN - 2072-6694
VL - 12
JO - Cancers
JF - Cancers
IS - 1
M1 - 62
ER -