The role of E3, E4 ubiquitin ligase (UBE4B) in human pathologies

Nikolaos Antoniou; Nefeli Lagopati; Dimitrios Ilias Balourdas; Michail Nikolaou; Alexandros Papalampros; Panagiotis V.S. Vasileiou; Vassilios Myrianthopoulos; Athanassios Kotsinas; Yosef Shiloh; Michalis Liontos; Vassilis G. Gorgoulis

doi:10.3390/cancers12010062

The role of E3, E4 ubiquitin ligase (UBE4B) in human pathologies

Nikolaos Antoniou, Nefeli Lagopati, Dimitrios Ilias Balourdas, Michail Nikolaou, Alexandros Papalampros, Panagiotis V.S. Vasileiou, Vassilios Myrianthopoulos, Athanassios Kotsinas^*, Yosef Shiloh, Michalis Liontos, Vassilis G. Gorgoulis

^*Corresponding author for this work

Human Molecular Genetics Biochemistry

Research output: Contribution to journal › Review article › peer-review

25 Scopus citations

Abstract

The genome is exposed daily to many deleterious factors. Ubiquitination is a mechanism that regulates several crucial cellular functions, allowing cells to react upon various stimuli in order to preserve their homeostasis. Ubiquitin ligases act as specific regulators and actively participate among others in the DNA damage response (DDR) network. UBE4B is a newly identified member of E3 ubiquitin ligases that appears to be overexpressed in several human neoplasms. The aim of this review is to provide insights into the role of UBE4B ubiquitin ligase in DDR and its association with p53 expression, shedding light particularly on the molecular mechanisms of carcinogenesis.

Original language	English
Article number	62
Journal	Cancers
Volume	12
Issue number	1
DOIs	https://doi.org/10.3390/cancers12010062
State	Published - Jan 2020

Funding

Funders	Funder number
National Strategic Reference Framework
Israel Cancer Research Fund
Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
European Commission
European Social Fund	Researchers-MIS5001552
Hellenic Society of Medical Oncology	70/3/12128, 70/3/9816

Keywords

Cancer disease
DNA damage response
P53
UBE4B
Ubiquitin ligases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3390/cancers12010062

Cite this

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abstract = "The genome is exposed daily to many deleterious factors. Ubiquitination is a mechanism that regulates several crucial cellular functions, allowing cells to react upon various stimuli in order to preserve their homeostasis. Ubiquitin ligases act as specific regulators and actively participate among others in the DNA damage response (DDR) network. UBE4B is a newly identified member of E3 ubiquitin ligases that appears to be overexpressed in several human neoplasms. The aim of this review is to provide insights into the role of UBE4B ubiquitin ligase in DDR and its association with p53 expression, shedding light particularly on the molecular mechanisms of carcinogenesis.",

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AU - Papalampros, Alexandros

AU - Vasileiou, Panagiotis V.S.

AU - Myrianthopoulos, Vassilios

AU - Kotsinas, Athanassios

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AU - Liontos, Michalis

AU - Gorgoulis, Vassilis G.

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The role of E3, E4 ubiquitin ligase (UBE4B) in human pathologies

Abstract

Funding

Keywords

UN SDGs

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