TY - JOUR
T1 - The Role of Cardiovascular Risk Factors in Alzheimer's Disease
AU - Ravona-Springer, Ramit
AU - Davidson, Michael
AU - Noy, Shlomo
PY - 2003/11
Y1 - 2003/11
N2 - The distinction between Alzheimer's disease and vascular dementia, the two most common types of dementia, has been undermined by recent advances in epidemiologic, clinical, imaging, and neuropathological studies. Cardiovascular risk factors, traditionally regarded as distinguishing criteria between the two entities, have been shown to be associated with both AD and vascular dementia. In this article, we propose mechanisms of action of cardiovascular risk factors in AD, suggest possible explanations for the overlap with vascular dementia and discuss the implications this might have on future differential diagnosis, research, and treatment strategies.
AB - The distinction between Alzheimer's disease and vascular dementia, the two most common types of dementia, has been undermined by recent advances in epidemiologic, clinical, imaging, and neuropathological studies. Cardiovascular risk factors, traditionally regarded as distinguishing criteria between the two entities, have been shown to be associated with both AD and vascular dementia. In this article, we propose mechanisms of action of cardiovascular risk factors in AD, suggest possible explanations for the overlap with vascular dementia and discuss the implications this might have on future differential diagnosis, research, and treatment strategies.
UR - http://www.scopus.com/inward/record.url?scp=1542647529&partnerID=8YFLogxK
U2 - 10.1017/S109285290001926X
DO - 10.1017/S109285290001926X
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AN - SCOPUS:1542647529
SN - 1092-8529
VL - 8
SP - 824
EP - 831
JO - CNS Spectrums
JF - CNS Spectrums
IS - 11
ER -