The role of bile acid excretion in atherosclerotic coronary artery disease

Gideon Charach*, Alexander Rabinovich, Ori Argov, Moshe Weintraub, Pavel Rabinovich

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations

Abstract

The impact of cholesterol and different classes of lipoproteins on the development of coronary artery disease (CAD) has been investigated in extensively during the past 50 years. The cholesterol metabolism is dependent on numerous factors, including dietary fat, fractional absorption of dietary cholesterol, tissue stores of cholesterol, endogenous cholesterol synthesis, and fecal bile excretion. Several studies showed significantly lower amounts of bile acid secretion in adult patients with CAD compared to non-CAD patients. Could it be that the inability to efficiently excrete bile acids may lead to CAD development?

Original languageEnglish
Article number949672
JournalInternational Journal of Vascular Medicine
Volume2012
DOIs
StatePublished - 2012
Externally publishedYes

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