TY - JOUR
T1 - The role of apolipoprotein E polymorphisms in levodopa-induced dyskinesia
AU - Molchadski, I.
AU - Korczyn, A. D.
AU - Cohen, O. S.
AU - Katzav, A.
AU - Nitzan, Z.
AU - Chapman, J.
AU - Hassin-Baer, S.
PY - 2011/2
Y1 - 2011/2
N2 - Objectives - To determine the relationship between apolipoprotein E (APOE) polymorphisms to the time to appearance of levodopa-induced dyskinesia (LID) in patients with Parkinson's disease.Methods - The APOE genotype of 155 consecutive patients treated with levodopa was determined and its effect on the time of onset of LID was examined using Cox regression model, controlling for gender, age of disease onset, time to initiation of levodopa treatment and history of smoking.Results - Two patients were homozygous for the APOE ε2 allele, 7 had ε2/ε3, 1 had ε2/ε4, 130 had ε3/ε3, 12 had ε3/ε4 and 3 had ε4/ε4; LID appeared in 57.4% of the patients, appearing 4.1 ± 3.5 years after the initiation of levodopa treatment. The survival curve for LID was not affected by the APOE genotype (P = 0.34).Conclusion - APOE polymorphisms were found not to be associated with either the occurrence or the time to development of LID.
AB - Objectives - To determine the relationship between apolipoprotein E (APOE) polymorphisms to the time to appearance of levodopa-induced dyskinesia (LID) in patients with Parkinson's disease.Methods - The APOE genotype of 155 consecutive patients treated with levodopa was determined and its effect on the time of onset of LID was examined using Cox regression model, controlling for gender, age of disease onset, time to initiation of levodopa treatment and history of smoking.Results - Two patients were homozygous for the APOE ε2 allele, 7 had ε2/ε3, 1 had ε2/ε4, 130 had ε3/ε3, 12 had ε3/ε4 and 3 had ε4/ε4; LID appeared in 57.4% of the patients, appearing 4.1 ± 3.5 years after the initiation of levodopa treatment. The survival curve for LID was not affected by the APOE genotype (P = 0.34).Conclusion - APOE polymorphisms were found not to be associated with either the occurrence or the time to development of LID.
KW - Apolipoprotein E
KW - Levodopa
KW - Levodopa-induced dyskinesias
KW - Parkinson's disease
KW - Polymorphism
UR - http://www.scopus.com/inward/record.url?scp=78650834663&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0404.2010.01352.x
DO - 10.1111/j.1600-0404.2010.01352.x
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C2 - 21108621
AN - SCOPUS:78650834663
SN - 0001-6314
VL - 123
SP - 117
EP - 121
JO - Acta Neurologica Scandinavica
JF - Acta Neurologica Scandinavica
IS - 2
ER -