The role of antibody-mediated immunity in defense against Mycobacterium tuberculosis: Advances toward a novel vaccine strategy

Aharona Glatman-Freedman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Antibody-mediated immunity has been historically considered to have no role in host-defense against Mycobacterium tuberculosis. In recent years, studies from our group as well as others have challenged this traditional thinking. Using monoclonal antibodies, researchers demonstrated that antibodies can modify various aspects of mycobacterial infection to the benefit of the host. A review of recent experimental evidence in support of a role for antibodies in host-defense against mycobacterial infections is presented. Challenges to the field and an outline of future directions with particular attention to research leading to the development of a novel vaccine strategy, are emphasized.

Original languageEnglish
Pages (from-to)191-197
Number of pages7
JournalTuberculosis
Volume86
Issue number3-4 SPEC. ISS.
DOIs
StatePublished - May 2006
Externally publishedYes

Funding

FundersFunder number
Sequella Global Tuberculosis Foundation
National Institutes of Health
National Institute of Allergy and Infectious DiseasesK08AI001691, R03AI053192

    Keywords

    • Antibody-mediated immunity
    • Monoclonal antibodies
    • Tuberculosis
    • Vaccine

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