The role of advanced MR methods in the diagnosis of cerebral amyloidoma

Erez Nossek*, Dafna Ben Bashat, Moran Artzi, Keren Rosenberg, Irith Lichter, Orit Shtern, Haim Ben Ami, Orna Aizenstein, Euvgeni Vlodavsky, Marius Constantinescu, Zvi Ram

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Amyloidoma is a term referring to a tumor-like deposition of extracellular insoluble fibrillar protein. Tumor-like amyloid formation in the brain had been described in isolated cases. However no advanced radiological studies to characterize these lesions have been reported. In the report, we have describe a 59-year-old woman, presented several months prior to diagnosis with memory decline, dizziness, walking instability, and speech difficulties. MRI revealed a left basal ganglia lesion with an intraventricular component. The patient underwent a stereotactic biopsy, which confirmed the diagnosis of amyloidoma, an extensive radiographic characterization of amyloidoma using advanced MR techniques was done, including magnetic resonance spectroscopy, dynamic susceptibility contrast, susceptibility weighted image SWI, and magnetization transfer MTR. All advanced MR techniques were able to characterize the amyloidoma as a non-neoplastic process. This is an example where such methods can be used for differential diagnosis of atypical brain lesions.

Original languageEnglish
Pages (from-to)94-98
Number of pages5
JournalAmyloid
Volume16
Issue number2
DOIs
StatePublished - 2009

Keywords

  • Cerebral amyloidoma
  • Diffusion tensor
  • Dynamic susceptibility
  • Magnetization transfer
  • Spectroscopy
  • Susceptibility weighted image
  • Tissue characterization

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