TY - JOUR
T1 - The role and biology of cryosurgery in the treatment of bone tumors
AU - Bickels, Jacob
AU - Meller, Isaac
AU - Shmookler, Barry M.
AU - Malawer, Martin M.
PY - 1999
Y1 - 1999
N2 - The application of liquid nitrogen as a local adjuvant to curettage in the treatment of bone tumors was introduced three decades ago. This technique, termed cryosurgery, was shown to achieve excellent local control in a variety of benign-aggressive and malignant bone tumors. However, early reports showed that cryosurgery was associated with a significant injury to the adjacent rim of bone and soft-tissue, resulting in high rates of fractures and infections. These results reflected an initial failure to appreciate the potentially destructive effects of liquid nitrogen and establish appropriate guidelines for its use. We review the biological effect of cryosurgery on bone, surgical technique, and current indications for its use.
AB - The application of liquid nitrogen as a local adjuvant to curettage in the treatment of bone tumors was introduced three decades ago. This technique, termed cryosurgery, was shown to achieve excellent local control in a variety of benign-aggressive and malignant bone tumors. However, early reports showed that cryosurgery was associated with a significant injury to the adjacent rim of bone and soft-tissue, resulting in high rates of fractures and infections. These results reflected an initial failure to appreciate the potentially destructive effects of liquid nitrogen and establish appropriate guidelines for its use. We review the biological effect of cryosurgery on bone, surgical technique, and current indications for its use.
UR - http://www.scopus.com/inward/record.url?scp=0032773816&partnerID=8YFLogxK
U2 - 10.3109/17453679908997814
DO - 10.3109/17453679908997814
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AN - SCOPUS:0032773816
SN - 0001-6470
VL - 70
SP - 308
EP - 315
JO - Acta Orthopaedica Scandinavica
JF - Acta Orthopaedica Scandinavica
IS - 3
ER -