TY - JOUR
T1 - The risk of tuberculosis in cancer patients is greatest in lymphoma and myelodysplastic syndrome/myeloproliferative neoplasm
T2 - a large population-based cohort study
AU - Ganzel, Chezi
AU - Silverman, Barbara
AU - Chemtob, Daniel
AU - Ben Shoham, Assaf
AU - Wiener-Well, Yonit
N1 - Publisher Copyright:
© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2019/2/23
Y1 - 2019/2/23
N2 - Patients with cancer are at high risk for tuberculosis (TB). This study combined the Israeli databases of cancer and TB and examined the development of TB among all newly diagnosed cancer cases from 1993 to 2013. Patients were classified into groups according to their different malignancies. Among 495,335 cancer patients, 335 developed TB following cancer diagnosis. The cumulative incidence of TB following cancer diagnosis was highest among MDS/MPN (148.8/100,000 patients) and lymphoma (154.1/100,000 patients) (p =.023). The HR of TB following cancer among hematologic patients was 2.51 (p <.001), relative to patients with in situ carcinomas/skin cancer and highest among MDS/MPN and lymphoma patients (2.74, p =.012 and 2.70, p <.001, respectively). Among lymphoma patients, a significant increased HR was found only among NHL patients (2.72, p <.001). The limitations include lack of information regarding risk factors for TB and of anti-cancer treatments. In conclusion, these data may encourage a heightened awareness for TB among patients with a background of lymphoma and MDS/MPN.
AB - Patients with cancer are at high risk for tuberculosis (TB). This study combined the Israeli databases of cancer and TB and examined the development of TB among all newly diagnosed cancer cases from 1993 to 2013. Patients were classified into groups according to their different malignancies. Among 495,335 cancer patients, 335 developed TB following cancer diagnosis. The cumulative incidence of TB following cancer diagnosis was highest among MDS/MPN (148.8/100,000 patients) and lymphoma (154.1/100,000 patients) (p =.023). The HR of TB following cancer among hematologic patients was 2.51 (p <.001), relative to patients with in situ carcinomas/skin cancer and highest among MDS/MPN and lymphoma patients (2.74, p =.012 and 2.70, p <.001, respectively). Among lymphoma patients, a significant increased HR was found only among NHL patients (2.72, p <.001). The limitations include lack of information regarding risk factors for TB and of anti-cancer treatments. In conclusion, these data may encourage a heightened awareness for TB among patients with a background of lymphoma and MDS/MPN.
KW - MDS
KW - MPN
KW - Tuberculosis
KW - cancer
KW - lymphoma
UR - http://www.scopus.com/inward/record.url?scp=85053341702&partnerID=8YFLogxK
U2 - 10.1080/10428194.2018.1499904
DO - 10.1080/10428194.2018.1499904
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C2 - 30188229
AN - SCOPUS:85053341702
SN - 1042-8194
VL - 60
SP - 720
EP - 725
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 3
ER -