The risk of cardiac complications following noncardiac surgery in patients with drug eluting stents implanted at least six months before surgery

Abid Assali, Hana Vaknin-Assa, Eli Lev, Tamir Bental, Itsik Ben-Dor, Igal Teplitsky, David Brosh, Shmuel Fuchs, Leonid Eidelman, Alexander Battler, Ran Kornowski*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Aims: Given the anecdotal reports and case series suggesting that drug-eluting coronary stents [DES] may be still vulnerable to coronary thrombosis after six months, we sought to assess this risk in patients undergoing non-cardiac surgery six months after stenting. Methods and Results: Linking the Rabin Medical Centre interventional cardiology database with its non-cardiac surgical database, we identified 78 patients who underwent DES placement and subsequently [after six months] had noncardiac surgery [15-vascular, 37- abdominal and genitourinary and 26-others, excluding ophthalmic surgery]. Outcome measures included 30-day rate of postoperative myocardial infarction (MI), DES-related thrombosis, and cardiac mortality. Major adverse cardiac events [death and non-fatal MI] occurred in 6 (7.7%) patients including 2 cardiac deaths (2.6%), 4 (5.1%) non-fatal myocardial infarctions (MIs). Two patients (2.6%) sustained stent thrombosis [one patient had 'definite' and one 'probable' stent thrombosis]. All MIs [including stent thrombosis] occurred in the vascular and abdominal surgery group. Two of the MIs events occurred while the patients were on dual antiplatelet agents. In conclusions: Perioperative cardiac events during non cardiac surgery after six months of DES deployment still occur. These cardiac complications [not entirely prevented by continued dual antiplatelet agents] remain a matter of diagnostic and therapeutic challenge and concern.

Original languageEnglish
Pages (from-to)837-843
Number of pages7
JournalCatheterization and Cardiovascular Interventions
Volume74
Issue number6
DOIs
StatePublished - 15 Nov 2009

Keywords

  • Drug-eluting stent
  • Noncardiac surgery
  • Stent thrombosis

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