TY - JOUR
T1 - The revised monoamine hypothesis
T2 - Mechanism of antidepressant treatment in the context of behavior
AU - Rotenberg, Vadim S.
PY - 1994/4
Y1 - 1994/4
N2 - The temporal restoration of brain monoamines in the synaptic cleft due to MAO inhibition or by blocking catecholamine reuptake is only the the first step on the way to recovery from depression. The second and crucial step represents the feedback system, which can provide the continuous restoration of brain monoamines in the context of free search behavior. This feedback system on the one hand helps to overcome depression and on the other hand causes the hyposensitivity of the postsynaptic catecholamine (CA) receptors, due to the increased activity of the brain CA system. According to the search activity concept, REM sleep in the healthy subject, being a part of the same feedback system, restores brain monoamines. The mechanism of REM sleep deprivation in the treatment of depression is discussed in the context of this feedback system.
AB - The temporal restoration of brain monoamines in the synaptic cleft due to MAO inhibition or by blocking catecholamine reuptake is only the the first step on the way to recovery from depression. The second and crucial step represents the feedback system, which can provide the continuous restoration of brain monoamines in the context of free search behavior. This feedback system on the one hand helps to overcome depression and on the other hand causes the hyposensitivity of the postsynaptic catecholamine (CA) receptors, due to the increased activity of the brain CA system. According to the search activity concept, REM sleep in the healthy subject, being a part of the same feedback system, restores brain monoamines. The mechanism of REM sleep deprivation in the treatment of depression is discussed in the context of this feedback system.
UR - http://www.scopus.com/inward/record.url?scp=0028417419&partnerID=8YFLogxK
U2 - 10.1007/BF02691013
DO - 10.1007/BF02691013
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C2 - 7947331
AN - SCOPUS:0028417419
SN - 1053-881X
VL - 29
SP - 182
EP - 188
JO - Integrative Physiological and Behavioral Science
JF - Integrative Physiological and Behavioral Science
IS - 2
ER -