The resilience framework as a strategy to combat stress-related disorders

Raffael Kalisch*, Dewleen G. Baker, Ulrike Basten, Marco P. Boks, George A. Bonanno, Eddie Brummelman, Andrea Chmitorz, Guillén Fernàndez, Christian J. Fiebach, Isaac Galatzer-Levy, Elbert Geuze, Sergiu Groppa, Isabella Helmreich, Talma Hendler, Erno J. Hermans, Tanja Jovanovic, Thomas Kubiak, Klaus Lieb, Beat Lutz, Marianne B. MüllerRyan J. Murray, Caroline M. Nievergelt, Andreas Reif, Karin Roelofs, Bart P.F. Rutten, David Sander, Anita Schick, Oliver Tüscher, Ilse Van Diest, Anne Laura Van Harmelen, Ilya M. Veer, Eric Vermetten, Christiaan H. Vinkers, Tor D. Wager, Henrik Walter, Michèle Wessa, Michael Wibral, Birgit Kleim

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

399 Scopus citations


Consistent failure over the past few decades to reduce the high prevalence of stress-related disorders has motivated a search for alternative research strategies. Resilience refers to the phenomenon of many people maintaining mental health despite exposure to psychological or physical adversity. Instead of aiming to understand the pathophysiology of stress-related disorders, resilience research focuses on protective mechanisms that shield people against the development of such disorders and tries to exploit its insights to improve treatment and, in particular, disease prevention. To fully harness the potential of resilience research, a critical appraisal of the current state of the art - in terms of basic concepts and key methods - is needed. We highlight challenges to resilience research and make concrete conceptual and methodological proposals to improve resilience research. Most importantly, we propose to focus research on the dynamic processes of successful adaptation to stressors in prospective longitudinal studies.

Original languageEnglish
Pages (from-to)784-790
Number of pages7
JournalNature Human Behaviour
Issue number11
StatePublished - 1 Nov 2017


FundersFunder number
National Institute of Health
Netherlands Brain FoundationF2013(1)-216, 451-13-001
National Institute of Mental Health1080, ERC-CoG682591, K01MH102415
National Institute of Mental Health
Rockefeller Foundation2012-RLC 304
Rockefeller Foundation
Horizon 2020 Framework Programme705217, 682591
Horizon 2020 Framework Programme
Chiropractic and Osteopathic College of AustralasiaERC_StG2012_313749
Chiropractic and Osteopathic College of Australasia
Royal SocietyDH150176
Royal Society
European CommissionC06, FI 848/5-1, H2020/705217
European Commission
European Research CouncilERC-CoG 617891, ERC-StG2012-313749
European Research Council
Deutsche ForschungsgemeinschaftCRC 1193
Deutsche Forschungsgemeinschaft
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungH2020/2014-2020, 100014-143398, 643051
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
United States-Israel Binational Science Foundation2013067
United States-Israel Binational Science Foundation
Nederlandse Organisatie voor Wetenschappelijk Onderzoek916-11-086, 453-12-001
Nederlandse Organisatie voor Wetenschappelijk Onderzoek


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