The relation between the clinical subtypes of delirium and the urinary level of 6-SMT

Silviu Balan, Arthur Leibovitz, Shen Orr Zila, Mishiev Ruth, Wechsler Chana, Blumenfeld Yassica, Biton Rahel, Goldstein Richard, Elon Neumann, Boris Blagman, Beni Habot

Research output: Contribution to journalArticlepeer-review

Abstract

Delirium is a common syndrome among hospitalized elderly patients. In humans, sleep and circadian rhythms are disturbed during delirium, and both are influenced by the hormone melatonin. This prompted us to investigate the relationship of the clinical subtypes of delirium: 1) hyperactive, 2) hypoactive, and 3) mixed, with melatonin, as reflected by a patient's urinary metabolite 6-SMT. Results support our hypothesis that urinary 6-SMT during delirium was higher in hypoactive and lower in hyperactive patients. Because this is the first time a biochemical parameter related to the clinical subtypes of delirium has been reported, further research on the link between melatonin and delirium is necessary.

Original languageEnglish
Pages (from-to)363-366
Number of pages4
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume15
Issue number3
DOIs
StatePublished - 2003

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