The relation between the clinical subtypes of delirium and the urinary level of 6-SMT

Silviu Balan; Arthur Leibovitz; Shen Orr Zila; Mishiev Ruth; Wechsler Chana; Blumenfeld Yassica; Biton Rahel; Goldstein Richard; Elon Neumann; Boris Blagman; Beni Habot

doi:10.1176/jnp.15.3.363

The relation between the clinical subtypes of delirium and the urinary level of 6-SMT

Silviu Balan, Arthur Leibovitz, Shen Orr Zila, Mishiev Ruth, Wechsler Chana, Blumenfeld Yassica, Biton Rahel, Goldstein Richard, Elon Neumann, Boris Blagman, Beni Habot

Clinical Departments

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Abstract

Delirium is a common syndrome among hospitalized elderly patients. In humans, sleep and circadian rhythms are disturbed during delirium, and both are influenced by the hormone melatonin. This prompted us to investigate the relationship of the clinical subtypes of delirium: 1) hyperactive, 2) hypoactive, and 3) mixed, with melatonin, as reflected by a patient's urinary metabolite 6-SMT. Results support our hypothesis that urinary 6-SMT during delirium was higher in hypoactive and lower in hyperactive patients. Because this is the first time a biochemical parameter related to the clinical subtypes of delirium has been reported, further research on the link between melatonin and delirium is necessary.

Original language	English
Pages (from-to)	363-366
Number of pages	4
Journal	Journal of Neuropsychiatry and Clinical Neurosciences
Volume	15
Issue number	3
DOIs	https://doi.org/10.1176/jnp.15.3.363
State	Published - 2003

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10.1176/jnp.15.3.363

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Balan, Silviu ; Leibovitz, Arthur ; Zila, Shen Orr ; Ruth, Mishiev ; Chana, Wechsler ; Yassica, Blumenfeld ; Rahel, Biton ; Richard, Goldstein ; Neumann, Elon ; Blagman, Boris ; Habot, Beni. / The relation between the clinical subtypes of delirium and the urinary level of 6-SMT. In: Journal of Neuropsychiatry and Clinical Neurosciences. 2003 ; Vol. 15, No. 3. pp. 363-366.

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abstract = "Delirium is a common syndrome among hospitalized elderly patients. In humans, sleep and circadian rhythms are disturbed during delirium, and both are influenced by the hormone melatonin. This prompted us to investigate the relationship of the clinical subtypes of delirium: 1) hyperactive, 2) hypoactive, and 3) mixed, with melatonin, as reflected by a patient's urinary metabolite 6-SMT. Results support our hypothesis that urinary 6-SMT during delirium was higher in hypoactive and lower in hyperactive patients. Because this is the first time a biochemical parameter related to the clinical subtypes of delirium has been reported, further research on the link between melatonin and delirium is necessary.",

author = "Silviu Balan and Arthur Leibovitz and Zila, {Shen Orr} and Mishiev Ruth and Wechsler Chana and Blumenfeld Yassica and Biton Rahel and Goldstein Richard and Elon Neumann and Boris Blagman and Beni Habot",

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The relation between the clinical subtypes of delirium and the urinary level of 6-SMT. / Balan, Silviu; Leibovitz, Arthur; Zila, Shen Orr; Ruth, Mishiev; Chana, Wechsler; Yassica, Blumenfeld; Rahel, Biton; Richard, Goldstein; Neumann, Elon; Blagman, Boris; Habot, Beni.

In: Journal of Neuropsychiatry and Clinical Neurosciences, Vol. 15, No. 3, 2003, p. 363-366.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The relation between the clinical subtypes of delirium and the urinary level of 6-SMT

AU - Balan, Silviu

AU - Leibovitz, Arthur

AU - Zila, Shen Orr

AU - Ruth, Mishiev

AU - Chana, Wechsler

AU - Yassica, Blumenfeld

AU - Rahel, Biton

AU - Richard, Goldstein

AU - Neumann, Elon

AU - Blagman, Boris

AU - Habot, Beni

PY - 2003

Y1 - 2003

N2 - Delirium is a common syndrome among hospitalized elderly patients. In humans, sleep and circadian rhythms are disturbed during delirium, and both are influenced by the hormone melatonin. This prompted us to investigate the relationship of the clinical subtypes of delirium: 1) hyperactive, 2) hypoactive, and 3) mixed, with melatonin, as reflected by a patient's urinary metabolite 6-SMT. Results support our hypothesis that urinary 6-SMT during delirium was higher in hypoactive and lower in hyperactive patients. Because this is the first time a biochemical parameter related to the clinical subtypes of delirium has been reported, further research on the link between melatonin and delirium is necessary.

AB - Delirium is a common syndrome among hospitalized elderly patients. In humans, sleep and circadian rhythms are disturbed during delirium, and both are influenced by the hormone melatonin. This prompted us to investigate the relationship of the clinical subtypes of delirium: 1) hyperactive, 2) hypoactive, and 3) mixed, with melatonin, as reflected by a patient's urinary metabolite 6-SMT. Results support our hypothesis that urinary 6-SMT during delirium was higher in hypoactive and lower in hyperactive patients. Because this is the first time a biochemical parameter related to the clinical subtypes of delirium has been reported, further research on the link between melatonin and delirium is necessary.

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SN - 0895-0172

IS - 3

ER -

The relation between the clinical subtypes of delirium and the urinary level of 6-SMT

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