The Regulatory Effect of Macrophages on the in Vitro Synthesis of IgE

Y. Levo, R. J. Harbeck, C. H. Kirkpatrick

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of indomethacin or macrophage‐depletion on the in vitro unstimulated and pokeweed mitogen (PWM)‐induced synthesis of IgG and IgE were compared. The effect on the unstimulated synthesis of IgG and IgE was similar, namely, no effect due to indomethacin and enhancement due to macrophage depletion. In contrast, the effect on PWM‐induced synthesis was dissimilar. Macrophage depletion enhanced IgG but inhibited IgE production. The effect of indomethacin paralleled that of macrophage depletion suggesting the involvement of prostaglandins. It seems that the regulatory effect of macrophages is different in the IgE system compared with the IgG system.

Original languageEnglish
Pages (from-to)229-232
Number of pages4
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume40
Issue number4
DOIs
StatePublished - May 1985
Externally publishedYes

Keywords

  • IgE synthesis
  • indomethacin
  • macrophages

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