TY - JOUR
T1 - The regulation of platelet aggregation in vitro by interleukin-1β and tumor necrosis factor-α
T2 - Changes in pregnancy and in pre-eclampsia
AU - Bar, J.
AU - Zosmer, A.
AU - Hod, M.
AU - Elder, M. G.
AU - Sullivan, M. H.F.
PY - 1997/10
Y1 - 1997/10
N2 - Platelet activation occurs in early pregnancy in women at risk of developing pre-eclampsia. Cytokines have been implicated in the pathogenesis of pre-eclampsia, so we determined the effects of interleukin-1β (IL-1β) and tumor necrosis factor-or (TNF-α) on the in vitro aggregation of human platelets. IL-1β increased aggregation of platelets from non-pregnant and pre-eclamptic women, and inhibited the aggregation of platelets from normal pregnant women. This latter effect was linked to a diminished P-selectin expression on ADP-stimulated whole blood platelets in normal pregnant women (p = 0.011). Platelet aggregation in response to ADP was found to be inhibited after preincubation with TNF-α in non-pregnant (38%, p = 0.01) and in normal pregnant women (54%, p = 0.001) and not affected in pre-eclamptic women. The inhibitory effects of TNF-α were mediated through the P75 receptor for TNF-α.
AB - Platelet activation occurs in early pregnancy in women at risk of developing pre-eclampsia. Cytokines have been implicated in the pathogenesis of pre-eclampsia, so we determined the effects of interleukin-1β (IL-1β) and tumor necrosis factor-or (TNF-α) on the in vitro aggregation of human platelets. IL-1β increased aggregation of platelets from non-pregnant and pre-eclamptic women, and inhibited the aggregation of platelets from normal pregnant women. This latter effect was linked to a diminished P-selectin expression on ADP-stimulated whole blood platelets in normal pregnant women (p = 0.011). Platelet aggregation in response to ADP was found to be inhibited after preincubation with TNF-α in non-pregnant (38%, p = 0.01) and in normal pregnant women (54%, p = 0.001) and not affected in pre-eclamptic women. The inhibitory effects of TNF-α were mediated through the P75 receptor for TNF-α.
UR - http://www.scopus.com/inward/record.url?scp=0030698776&partnerID=8YFLogxK
U2 - 10.1055/s-0038-1657724
DO - 10.1055/s-0038-1657724
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AN - SCOPUS:0030698776
SN - 0340-6245
VL - 78
SP - 1255
EP - 1261
JO - Thrombosis and Haemostasis
JF - Thrombosis and Haemostasis
IS - 4
ER -