The regulation of platelet aggregation in vitro by interleukin-1β and tumor necrosis factor-α: Changes in pregnancy and in pre-eclampsia

J. Bar, A. Zosmer, M. Hod, M. G. Elder, M. H.F. Sullivan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Platelet activation occurs in early pregnancy in women at risk of developing pre-eclampsia. Cytokines have been implicated in the pathogenesis of pre-eclampsia, so we determined the effects of interleukin-1β (IL-1β) and tumor necrosis factor-or (TNF-α) on the in vitro aggregation of human platelets. IL-1β increased aggregation of platelets from non-pregnant and pre-eclamptic women, and inhibited the aggregation of platelets from normal pregnant women. This latter effect was linked to a diminished P-selectin expression on ADP-stimulated whole blood platelets in normal pregnant women (p = 0.011). Platelet aggregation in response to ADP was found to be inhibited after preincubation with TNF-α in non-pregnant (38%, p = 0.01) and in normal pregnant women (54%, p = 0.001) and not affected in pre-eclamptic women. The inhibitory effects of TNF-α were mediated through the P75 receptor for TNF-α.

Original languageEnglish
Pages (from-to)1255-1261
Number of pages7
JournalThrombosis and Haemostasis
Volume78
Issue number4
DOIs
StatePublished - Oct 1997

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