The regional cerebral blood flow in patients under chronic hemodialytic treatment.

D. Gottlieb, B. Mildworf, D. Rubinger, E. Melamed

Research output: Contribution to journalArticlepeer-review


Regional cerebral blood flow (rCBF) was measured by the xenon-133 inhalation method in an unselected group of nine chronic hemodialysis patients before and after a single hemodialytic treatment. All patients underwent neurological, neuropsychological, and biochemical evaluations on the same occasions. Predialysis rCBF values did not differ from those obtained in age-matched normal controls. Following hemodialysis, there was a mild reduction in the rCBF by a mean of 7 +/- 2.6% (p = 0.02). The posthemodialysis rCBF reduction was not associated with any neurological or cognitive dysfunction. The causes of hemodialysis-induced rCBF decreases are unknown, but increased blood viscosity and biochemical changes, such as urea reduction and blood alkalinization, may play a role.

Original languageEnglish
Pages (from-to)659-661
Number of pages3
JournalJournal of Cerebral Blood Flow and Metabolism
Issue number5
StatePublished - Oct 1987
Externally publishedYes


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