The rate of the recurrent MSH6 mutations in Ashkenazi Jewish breast cancer patients

Rinat Bernstein-Molho, Yael Laitman, Hagit Schayek, Sarah Iomdin, Eitan Friedman

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Whether breast cancer (BC) should be considered within the spectrum of tumors in Lynch syndrome (LS) is unsettled. Recently, MSH6 and PMS2 germline mutations have reportedly been associated with an increased BC risk and with hereditary breast and ovarian cancer (HBOC) phenotype. We assessed the rates of the recurring Ashkenazi Jewish (AJ) mutations in the MSH6 gene (c.3984_3987dupGTCA and c.3959_3962delCAAG) in AJ cases with seemingly sporadic BC or HBOC phenotype, who were negative for the founder AJ BRCA1/2 mutations. Methods: All AJ individuals, affected with BC ≤ 70 years and/or ovarian cancer at any age who were counseled, genotyped and tested negative for the BRCA1/2 founder mutations between January 2010 and February 2018 at the Oncogenetics unit, Sheba Medical Center, were genotyped for the AJ mutations in MSH6. Results: Of 1016 genotyped participants (815 BC cases, 132 ovarian cancer cases, and 69 with more than one cancer), five carriers (0.49%) of the recurring AJ mutations in MSH6 were identified. All had BC, and two had personal history of additional cancers (pancreatic, endometrial, colorectal). The rate of MSH6 mutations was 0.93% (4/429) when considering only cases with a personal or first-degree relative with LS-related cancer, and 0.17% (1/587) of cases with second-degree relative or no family history of LS-related cancers (p = 0.087). Conclusions: Our data suggest the spectrum of genotyped mutations in AJ BC patients with a personal or family history of LS-related cancers should be expanded. These data should be validated in other populations with a similar phenotype.

Original languageEnglish
Pages (from-to)97-101
Number of pages5
JournalCancer Causes and Control
Volume30
Issue number1
DOIs
StatePublished - 1 Jan 2019

Keywords

  • Ashkenazi Jews
  • Breast cancer
  • Lynch syndrome
  • MSH6

Fingerprint

Dive into the research topics of 'The rate of the recurrent MSH6 mutations in Ashkenazi Jewish breast cancer patients'. Together they form a unique fingerprint.

Cite this