The Ras inhibitor S-trans, trans-farnesylthiosalicylic acid exerts long-lasting neuroprotection in a mouse closed head injury model

Keyphrases

• Farnesylthiosalicylic Acid 100%
• RAS Inhibitors 100%
• S-trans 100%
• Neuroprotection 100%
• Closed Head Injury 100%
• Head Injury Model 100%
• N-methyl-D-aspartate Receptor (NMDAR) 42%
• MK-801 28%
• Receptor Binding 28%
• Traumatic Brain Injury 28%
• Neurologic Deficit 28%
• Striatal 14%
• Parahippocampal Region 14%
• Cell Growth 14%
• NMDA Receptor Antagonist 14%
• Cell Death 14%
• Inhibition Rate 14%
• Phosphorylated Extracellular Signal-regulated Kinase 14%
• Trauma Symptoms 14%
• Cortical Regions 14%
• Mouse Model 14%
• Cell Survival 14%
• Active Ras 14%
• Fold Increase 14%
• Ras Proteins 14%
• Lesion Size 14%
• Neuroprotective Drugs 14%
• Autoradiography 14%
• Long-term Neuroprotection 14%

Neuroscience

• Closed Head Injury 100%
• Neuroprotection 100%
• Aspartic Acid 50%
• Receptor Binding 33%
• Neurotrauma 33%
• Traumatic Brain Injury 33%
• Guanosine Triphosphate 33%
• Neuroprotective Agent 16%
• NMDA Receptor Antagonist 16%
• Cell Growth 16%
• Extracellular Signal-Regulated Kinases 16%
• Cell Death 16%
• Cell Survival 16%
• Ras Protein 16%
• Autoradiograph 16%
• Receptor 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Salirasib 100%
• Neuroprotection 100%
• Head Injury 100%
• Aspartic Acid 42%
• Receptor 42%
• Guanosine Triphosphate 28%
• Traumatic Brain Injury 28%
• N Methyl Dextro Aspartic Acid Receptor Blocking Agent 14%
• Mitogen Activated Protein Kinase 14%
• Mouse Model 14%
• Neuroprotective Agent 14%
• Ras Protein 14%
• Autoradiography 14%