TY - JOUR
T1 - The pyruvate kinase isoenzyme M2 (Tu M2-PK) as a tumour marker for renal cell carcinoma
T2 - Original article
AU - Weinberger, R.
AU - Appel, B.
AU - Stein, A.
AU - Metz, Y.
AU - Neheman, A.
AU - Barak, M.
PY - 2007/7
Y1 - 2007/7
N2 - The M2 isoenzyme of pyruvate kinase (M2-PK) is specially expressed by tumour cells (Tu M2-PK) and has been detected in the peripheral blood of patients with renal cell carcinoma (RCC). We analysed the benefit of using Tu M2-PK as a tumour marker for primary detection of RCC by receiver operating characteristic (ROC) analysis. The area under the curve was 0.674, and the sensitivity, specificity and positive predictive value (PPV) were 44.4?, 87.5? and 88?, respectively, at the ROC optimal cut-off of 28.2 kU/L. We examined 71 patients. Since the marker sensitivity for detection of the early stages T1 and T2 was only 47? it is not suggested to use this marker for primary diagnosis of RCC. Its use as part of the confirmatory preoperative evaluation might be considered in view of its high PPV.
AB - The M2 isoenzyme of pyruvate kinase (M2-PK) is specially expressed by tumour cells (Tu M2-PK) and has been detected in the peripheral blood of patients with renal cell carcinoma (RCC). We analysed the benefit of using Tu M2-PK as a tumour marker for primary detection of RCC by receiver operating characteristic (ROC) analysis. The area under the curve was 0.674, and the sensitivity, specificity and positive predictive value (PPV) were 44.4?, 87.5? and 88?, respectively, at the ROC optimal cut-off of 28.2 kU/L. We examined 71 patients. Since the marker sensitivity for detection of the early stages T1 and T2 was only 47? it is not suggested to use this marker for primary diagnosis of RCC. Its use as part of the confirmatory preoperative evaluation might be considered in view of its high PPV.
KW - Area under the curve
KW - Pyruvate kinase isoenzymes
KW - Receiver operating characteristic analysis
KW - Renal cell carcinoma
KW - Tu M2-PK
KW - Tumour marker
UR - http://www.scopus.com/inward/record.url?scp=34250869086&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2354.2006.00753.x
DO - 10.1111/j.1365-2354.2006.00753.x
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C2 - 17587357
AN - SCOPUS:34250869086
SN - 0961-5423
VL - 16
SP - 333
EP - 337
JO - European Journal of Cancer Care
JF - European Journal of Cancer Care
IS - 4
ER -
