The Protective Role of Helminths in Autoimmunity

Tomer Bashi, Tom Konikoff, Miri Blank, Yehuda Shoenfeld

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Autoimmune diseases prevalence has grown throughout the last century, mostly in the western world. Helminths, their ova and their derivatives were found to have a protective role in autoimmunity and inflammatory conditions. Helminths were found to manipulate the immune network by attenuating the host's cellular and humoral responses. Indeed, various helminths species used in several human and animal models were shown to limit inflammatory activity in a variety of autoimmune diseases [e.g. inflammatory bowel disease, multiple sclerosis, lupus, type 1 diabetes, rheumatoid arthritis and Graves' disease]. Our review will focus on those autoimmune diseases in which helminths and their derivatives demonstrated a therapeutic potential.

Original languageEnglish
Title of host publicationInfection and Autoimmunity
PublisherElsevier Inc.
Pages199-216
Number of pages18
ISBN (Print)9780444632692
DOIs
StatePublished - 1 Jan 2015

Keywords

  • Animal models
  • Autoimmune diseases
  • Cytokines
  • Helminths
  • Immune System
  • Inflammation

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