The Protective Discourse Between Infections and Autoimmunity

Prashant S. Giri; Yehuda Shoenfeld; Mitesh Kumar Dwivedi

doi:10.1007/978-981-19-4800-8_4

The Protective Discourse Between Infections and Autoimmunity

Prashant S. Giri, Yehuda Shoenfeld, Mitesh Kumar Dwivedi^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

Autoimmune diseases are characterized by aberrant immune response against host own tissues. Studies have suggested that through molecular mimicry, bystander activation, and cross-reactivity, infections can trigger autoimmune diseases. However, paradoxically recent studies have highlighted the role of bacteria, viruses, and parasites in protection against autoimmune diseases. Epidemiological evidences and hygiene hypothesis also highlight the involvement of microbes in protection against autoimmune diseases. Interestingly, the data suggests increased incidence of the autoimmune diseases in developed countries. Microorganisms can protect against autoimmune diseases by antigenic competition, innate immune mechanisms, immune regulation; however, the detailed mechanisms underlying the involvement of microorganisms in protection of autoimmune diseases is unknown. The detailed understanding of mechanisms involved could lead to efficient therapeutics to treat autoimmune diseases.

Original language	English
Title of host publication	Role of Microorganisms in Pathogenesis and Management of Autoimmune Diseases
Subtitle of host publication	Volume II: Kidney, Central Nervous System, Eye, Blood, Blood Vessels and Bowel
Publisher	Springer Nature
Pages	85-107
Number of pages	23
Volume	2
ISBN (Electronic)	9789811948008
ISBN (Print)	9789811947995
DOIs	https://doi.org/10.1007/978-981-19-4800-8_4
State	Published - 1 Jan 2023
Externally published	Yes

Keywords

Antigenic competition
Autoimmunity
Immune regulation
Infection
Innate immunity

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10.1007/978-981-19-4800-8_4

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abstract = "Autoimmune diseases are characterized by aberrant immune response against host own tissues. Studies have suggested that through molecular mimicry, bystander activation, and cross-reactivity, infections can trigger autoimmune diseases. However, paradoxically recent studies have highlighted the role of bacteria, viruses, and parasites in protection against autoimmune diseases. Epidemiological evidences and hygiene hypothesis also highlight the involvement of microbes in protection against autoimmune diseases. Interestingly, the data suggests increased incidence of the autoimmune diseases in developed countries. Microorganisms can protect against autoimmune diseases by antigenic competition, innate immune mechanisms, immune regulation; however, the detailed mechanisms underlying the involvement of microorganisms in protection of autoimmune diseases is unknown. The detailed understanding of mechanisms involved could lead to efficient therapeutics to treat autoimmune diseases.",

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The Protective Discourse Between Infections and Autoimmunity. / Giri, Prashant S.; Shoenfeld, Yehuda; Dwivedi, Mitesh Kumar.
Role of Microorganisms in Pathogenesis and Management of Autoimmune Diseases: Volume II: Kidney, Central Nervous System, Eye, Blood, Blood Vessels and Bowel. Vol. 2 Springer Nature, 2023. p. 85-107.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

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N2 - Autoimmune diseases are characterized by aberrant immune response against host own tissues. Studies have suggested that through molecular mimicry, bystander activation, and cross-reactivity, infections can trigger autoimmune diseases. However, paradoxically recent studies have highlighted the role of bacteria, viruses, and parasites in protection against autoimmune diseases. Epidemiological evidences and hygiene hypothesis also highlight the involvement of microbes in protection against autoimmune diseases. Interestingly, the data suggests increased incidence of the autoimmune diseases in developed countries. Microorganisms can protect against autoimmune diseases by antigenic competition, innate immune mechanisms, immune regulation; however, the detailed mechanisms underlying the involvement of microorganisms in protection of autoimmune diseases is unknown. The detailed understanding of mechanisms involved could lead to efficient therapeutics to treat autoimmune diseases.

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The Protective Discourse Between Infections and Autoimmunity

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Keywords

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