TY - JOUR
T1 - The prognostic value and significance of preclinical abortions in in vitro fertilization-embryo transfer programs
AU - Levy, T.
AU - Dicker, D.
AU - Ashkenazi, J.
AU - Feldberg, D.
AU - Shelef, M.
AU - Goldman, J. A.
PY - 1991
Y1 - 1991
N2 - Preclinical abortions occur in natural conceptions as well as in in vitro fertilization-embryo transfer (IVF-ET) cycles. Nevertheless, although known, this entity is ill defined. Objective: The purpose of this study was to propose a classification of these pregnancies on the basis of pathophysiological evidence and to evaluate their future clinical impact. Design: Of 970 IVF-ET cycles, 114 cycles (11.7%) terminated in preclinical abortions. Abortions were divided according to peak beta human chorionic gonadotropin (β-hCG) values into chemical abortions (52%) occurring 2 weeks after ET with β-hCG values not higher than 21 mIU/mL and peri-implantation abortions (47%) terminating spontaneously 4 weeks after ET; the latter had higher β-hCG values for a longer period of time but without any sonographic evidence of gestational sac. No woman in the two groups needed curettage. Results: After a chemical abortion, the pregnancy outcome had better ongoing pregnancy rates (24.7%) in comparison with the 17% achieved in the total IVF-ET cycles. Conclusions: It is concluded that these two groups most probably have different pathophysiological backgrounds and concomitantly different future clinical impacts.
AB - Preclinical abortions occur in natural conceptions as well as in in vitro fertilization-embryo transfer (IVF-ET) cycles. Nevertheless, although known, this entity is ill defined. Objective: The purpose of this study was to propose a classification of these pregnancies on the basis of pathophysiological evidence and to evaluate their future clinical impact. Design: Of 970 IVF-ET cycles, 114 cycles (11.7%) terminated in preclinical abortions. Abortions were divided according to peak beta human chorionic gonadotropin (β-hCG) values into chemical abortions (52%) occurring 2 weeks after ET with β-hCG values not higher than 21 mIU/mL and peri-implantation abortions (47%) terminating spontaneously 4 weeks after ET; the latter had higher β-hCG values for a longer period of time but without any sonographic evidence of gestational sac. No woman in the two groups needed curettage. Results: After a chemical abortion, the pregnancy outcome had better ongoing pregnancy rates (24.7%) in comparison with the 17% achieved in the total IVF-ET cycles. Conclusions: It is concluded that these two groups most probably have different pathophysiological backgrounds and concomitantly different future clinical impacts.
UR - http://www.scopus.com/inward/record.url?scp=0025779019&partnerID=8YFLogxK
U2 - 10.1016/S0015-0282(16)54419-7
DO - 10.1016/S0015-0282(16)54419-7
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AN - SCOPUS:0025779019
SN - 0015-0282
VL - 56
SP - 71
EP - 74
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 1
ER -