TY - JOUR
T1 - The prognostic role of the extent of Y microdeletion on spermatogenesis and maturity of Sertoli cells
AU - Kleiman, S. E.
AU - Maymon, B. Bar Shira
AU - Yogev, L.
AU - Paz, G.
AU - Yavetz, H.
PY - 2001
Y1 - 2001
N2 - Substantial involvement of the Y chromosome in sexual development and spermatogenesis has been demonstrated. Over the last decade, varying extent of Y chromosome microdeletions have been identified among infertile patients with azoospermia or oligozoospermia. These microdeletions were clustered in three main regions named AZFa, AZFb, and AZFc. Analysis of the Y chromosome microdeletion was found to be of prognostic value in cases of infertility, both in terms of clinical management as well as for understanding the aetiology of the spermatogenesis impairment. However, the accumulated data are difficult to analyse, due to the variable extent of these deletions, the different sequence-tagged sites (STS) used to detect the microdeletions, and the non-uniformity of the histological terminology used by different investigators. This debate discusses the chances of finding testicular spermatozoa in men with a varying extent of Y chromosome microdeletions. The genotype and germ cell findings in men with AZFa microdeletions as well as those that include more than a single AZF region are reviewed, as is the effect of Y chromosome AZF microdeletions on the maturity of the Sertoli cells.
AB - Substantial involvement of the Y chromosome in sexual development and spermatogenesis has been demonstrated. Over the last decade, varying extent of Y chromosome microdeletions have been identified among infertile patients with azoospermia or oligozoospermia. These microdeletions were clustered in three main regions named AZFa, AZFb, and AZFc. Analysis of the Y chromosome microdeletion was found to be of prognostic value in cases of infertility, both in terms of clinical management as well as for understanding the aetiology of the spermatogenesis impairment. However, the accumulated data are difficult to analyse, due to the variable extent of these deletions, the different sequence-tagged sites (STS) used to detect the microdeletions, and the non-uniformity of the histological terminology used by different investigators. This debate discusses the chances of finding testicular spermatozoa in men with a varying extent of Y chromosome microdeletions. The genotype and germ cell findings in men with AZFa microdeletions as well as those that include more than a single AZF region are reviewed, as is the effect of Y chromosome AZF microdeletions on the maturity of the Sertoli cells.
KW - CK-18
KW - Chromosomal instability
KW - Infertility
KW - Spermatogenesis
KW - Y chromosome microdeletion
UR - http://www.scopus.com/inward/record.url?scp=0035107689&partnerID=8YFLogxK
U2 - 10.1093/humrep/16.3.399
DO - 10.1093/humrep/16.3.399
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C2 - 11228202
AN - SCOPUS:0035107689
SN - 0268-1161
VL - 16
SP - 399
EP - 402
JO - Human Reproduction
JF - Human Reproduction
IS - 3
ER -