The prevention and management of Crohn's disease postoperative recurrence: Results from the Y-ECCO/ClinCom 2019 Survey

Gabriele Dragoni, Nik Ding, Krisztina B. Gecse, John C. Mansfield, Uri Kopylov, Laurent Beaugerie, Peter Bossuyt, Shaji Sebastian, Monica Milla, Siro Bagnoli, Nuha A. Yassin, Dominik Bettenworth, Johan Burisch, Charlotte Hedin, Javier P. Gisbert, Marc Ferrante

Research output: Contribution to journalReview articlepeer-review


Background: Prevention and management of postoperative recurrence (POR) is a controversial field in Crohn's disease. The aim of this survey was to report common practice in real-life settings. Methods: An 11-question survey was distributed among gastroenterologists attending the 14th European Crohn's and Colitis Organisation (ECCO) congress. Results: Postoperative endoscopy to assess recurrence was routinely performed within 12 months by 87% of respondents. Forty-six percent of clinicians reported to maintain endoscopic assessment in routine follow-up even after first negative colonoscopy. Most respondents (60%) considered starting postoperative immunoprophylaxis in naïve patients if one or more known risk factors were present. The number of risk factors was an important driver for prescribing biologics over immunosuppressants for 60% of respondents. In case of fistulizing phenotype, perianal disease, or concomitant colonic involvement, the majority of physicians reported to start an immediate prophylaxis in 85, 98 and 88% of patients, respectively. A significant percentage of clinicians were more prone to an endoscopy-driven treatment in long-standing disease after failure of thiopurines (51%) and elderly (43%). Conclusion: Endoscopy within the first year after surgery to assess POR has become routine in most centres. The high rate of early prophylaxis with expensive biologics despite missing solid evidence highlights the need for more randomized trials.

Original languageEnglish
Pages (from-to)1062-1066
Number of pages5
JournalEuropean Journal of Gastroenterology and Hepatology
StateAccepted/In press - 2020
Externally publishedYes


  • biologics
  • Crohn's disease
  • immunoprophylaxis
  • postoperative recurrence
  • prevention


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