TY - JOUR
T1 - The Prevalence of Coronary Microvascular Dysfunction in Patients With Type 2 Diabetes Mellitus
AU - Chitturi, Kalyan R.
AU - Kumar, Sant
AU - Frisancho, Flavia Tejada
AU - Rahman, Sana
AU - Verma, Beni Rai
AU - Cellamare, Matteo
AU - Merdler, Ilan
AU - Ozturk, Sevket Tolga
AU - Cermak, Vijoli
AU - Sawant, Vaishnavi
AU - Zhang, Cheng
AU - Ben-Dor, Itsik
AU - Waksman, Ron
AU - Hashim, Hayder D.
AU - Case, Brian C.
N1 - Publisher Copyright:
© 2025 Wiley Periodicals LLC.
PY - 2025/4/1
Y1 - 2025/4/1
N2 - Patients with type 2 diabetes mellitus (DM) are more susceptible to microvascular complications. However, whether DM is associated with coronary microvascular dysfunction (CMD) is unclear. This observational study used data from the Coronary Microvascular Disease Registry (CMDR) (NCT05960474) and included patients with angina and no obstructive coronary artery disease (ANOCA) who underwent invasive CMD evaluation using the CoroVentis CoroFlow System (Abbott Vascular, Santa Clara, CA). Patient demographics, comorbidities, laboratory data, echocardiography, coronary angiography, and microvascular physiology results were analyzed. Among the 271 patients, 73 (26.9%) had DM. These patients were more likely to be African American (68.1% vs. 47.0%) and had higher rates of hypertension (93.2% vs. 74.2%), hyperlipidemia (89.0% vs. 68.7%), and chronic kidney disease (17.8% vs. 8.1%) than those without DM. Invasive coronary functional testing showed no significant differences in the index of microcirculatory resistance (IMR) (17.82 ± 8.17 vs. 19.37 ± 13.14, p = 0.268) or coronary flow reserve (CFR) (3.24 ± 1.73 vs. 3.21 ± 1.86, p = 0.909) between diabetic and nondiabetic patients. Similarly, in those testing positive for CMD, there were no significant differences in IMR (27.8 ± 7.4 vs. 32.35 ± 15.22, p = 0.108) or CFR (2.42 ± 1.09 vs. 2.05 ± 0.94, p = 0.199). Although patients with DM exhibited more comorbidities, CMD physiology indices were comparable between the groups.
AB - Patients with type 2 diabetes mellitus (DM) are more susceptible to microvascular complications. However, whether DM is associated with coronary microvascular dysfunction (CMD) is unclear. This observational study used data from the Coronary Microvascular Disease Registry (CMDR) (NCT05960474) and included patients with angina and no obstructive coronary artery disease (ANOCA) who underwent invasive CMD evaluation using the CoroVentis CoroFlow System (Abbott Vascular, Santa Clara, CA). Patient demographics, comorbidities, laboratory data, echocardiography, coronary angiography, and microvascular physiology results were analyzed. Among the 271 patients, 73 (26.9%) had DM. These patients were more likely to be African American (68.1% vs. 47.0%) and had higher rates of hypertension (93.2% vs. 74.2%), hyperlipidemia (89.0% vs. 68.7%), and chronic kidney disease (17.8% vs. 8.1%) than those without DM. Invasive coronary functional testing showed no significant differences in the index of microcirculatory resistance (IMR) (17.82 ± 8.17 vs. 19.37 ± 13.14, p = 0.268) or coronary flow reserve (CFR) (3.24 ± 1.73 vs. 3.21 ± 1.86, p = 0.909) between diabetic and nondiabetic patients. Similarly, in those testing positive for CMD, there were no significant differences in IMR (27.8 ± 7.4 vs. 32.35 ± 15.22, p = 0.108) or CFR (2.42 ± 1.09 vs. 2.05 ± 0.94, p = 0.199). Although patients with DM exhibited more comorbidities, CMD physiology indices were comparable between the groups.
KW - ANOCA
KW - angina with nonobstructive coronary arteries
KW - arrhythmia
KW - coronary microvascular dysfunction
KW - diabetes
UR - http://www.scopus.com/inward/record.url?scp=85216449886&partnerID=8YFLogxK
U2 - 10.1002/ccd.31429
DO - 10.1002/ccd.31429
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C2 - 39888248
AN - SCOPUS:85216449886
SN - 1522-1946
VL - 105
SP - 1120
EP - 1123
JO - Catheterization and Cardiovascular Interventions
JF - Catheterization and Cardiovascular Interventions
IS - 5
ER -
