The predictive role of preoperative and postoperative neutrophil-lymphocyte ratio in sarcomatoid renal cell carcinoma

Roy Mano, Jessica Flynn, Kyle A. Blum, Andrew W. Silagy, Renzo G. DiNatale, Julian Marcon, Alan Wang, Alejandro Sanchez, Jonathan A. Coleman, Paul Russo, Irina Ostrovnaya, A. Ari Hakimi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objective: Preoperative inflammatory parameters are associated with outcome in renal cell carcinoma; however, their predictive value in tumors with sarcomatoid dedifferentiation (sRCC) is uncertain. We aimed to evaluate the association between preoperative and postoperative inflammatory parameters and the outcome of patients with locoregional and metastatic sRCC who underwent nephrectomy. Methods and materials: After obtaining IRB approval, we identified 230 patients with sRCC treated between 1994 and 2018 with a complete blood count drawn ≤1 month before nephrectomy. Preoperative neutrophil-lymphocyte ratio (NLR), lymphocyte-monocyte ratio, and platelet-lymphocyte ratio were evaluated as continuous variables. Postoperative NLR, 1 to 8 weeks after surgery, and percentage change in NLR were calculated. Cox regression models were used to identify predictors of outcome. Results: The study cohort included 105 metastatic patients and 112 patients with locoregional disease. Patients with metastatic disease had significantly higher preoperative NLR (4.31 vs. 3.29) and PLR (248 vs. 194), and lower preoperative LMR (2.6 vs. 3.23). Median follow-up for patients with locoregional and metastatic disease was 36 months and 20 months, respectively, and estimated 5-year cancer-specific survival (CSS) rates were 56% and 15%, respectively. Preoperative NLR was a significant predictor of CSS for both metastatic (HR = 1.23, 95% CI 1.1–1.37, P < 0.001) and locoregional (HR = 1.09, 95% CI 1–1.2, P = 0.049) patients. For metastatic patients, postoperative NLR was significantly associated with CSS on univariate analysis; however, change in NLR was not associated with outcome. Conclusions: Preoperative NLR is associated with CSS in locoregional and metastatic sRCC. NLR should be considered when establishing future predictive models for sRCC.

Original languageEnglish
Pages (from-to)916-923
Number of pages8
JournalUrologic Oncology: Seminars and Original Investigations
Issue number12
StatePublished - Dec 2019
Externally publishedYes


  • Kidney
  • Lymphocytes
  • Neutrophils
  • Prognosis
  • Sarcomatoid renal cell carcinoma


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