TY - JOUR
T1 - The potential biological and clinical significance of the soluble tumor necrosis factor receptors
AU - Aderka, Dan
PY - 1996/10
Y1 - 1996/10
N2 - The role of TNF receptors (TNF-Rs) is not limited to signal transduction but includes extracellular regulatory functions affecting systemic TNF bioavailability. This review summarizes the regulation of TNF-R shedding and its kinetics, the complex interaction between the soluble receptors and their ligand in vitro and in vivo, and the potential diagnostic, prognostic and therapeutic value of the soluble receptors in malignant, inflammatory, infectious and autoimmune disorders.
AB - The role of TNF receptors (TNF-Rs) is not limited to signal transduction but includes extracellular regulatory functions affecting systemic TNF bioavailability. This review summarizes the regulation of TNF-R shedding and its kinetics, the complex interaction between the soluble receptors and their ligand in vitro and in vivo, and the potential diagnostic, prognostic and therapeutic value of the soluble receptors in malignant, inflammatory, infectious and autoimmune disorders.
KW - Receptor
KW - Tumor necrosis factor
UR - http://www.scopus.com/inward/record.url?scp=0030265258&partnerID=8YFLogxK
U2 - 10.1016/S1359-6101(96)00026-3
DO - 10.1016/S1359-6101(96)00026-3
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AN - SCOPUS:0030265258
SN - 1359-6101
VL - 7
SP - 231
EP - 240
JO - Cytokine and Growth Factor Reviews
JF - Cytokine and Growth Factor Reviews
IS - 3
ER -
