The potential biological and clinical significance of the soluble tumor necrosis factor receptors

Dan Aderka*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

Abstract

The role of TNF receptors (TNF-Rs) is not limited to signal transduction but includes extracellular regulatory functions affecting systemic TNF bioavailability. This review summarizes the regulation of TNF-R shedding and its kinetics, the complex interaction between the soluble receptors and their ligand in vitro and in vivo, and the potential diagnostic, prognostic and therapeutic value of the soluble receptors in malignant, inflammatory, infectious and autoimmune disorders.

Original languageEnglish
Pages (from-to)231-240
Number of pages10
JournalCytokine and Growth Factor Reviews
Volume7
Issue number3
DOIs
StatePublished - Oct 1996

Keywords

  • Receptor
  • Tumor necrosis factor

Fingerprint

Dive into the research topics of 'The potential biological and clinical significance of the soluble tumor necrosis factor receptors'. Together they form a unique fingerprint.

Cite this