TY - JOUR
T1 - The Popdc gene family in the rat
T2 - Molecular cloning, characterization and expression analysis in the heart and cultured cardiomyocytes
AU - Parnes, Doris
AU - Jacoby, Vered
AU - Sharabi, Avital
AU - Schlesinger, Hadassa
AU - Brand, Thomas
AU - Kessler-Icekson, Gania
N1 - Funding Information:
We thank Mariano Schumann (MSc) and Amir Kremer (BSc) for their assistance in part of the RT-PCR analyses, and the financial support by the German-Israeli Foundation (GIF), grants No. I-141-202.01/96 and I-669-91.2/00, to G.K-I and TB.
PY - 2007/9
Y1 - 2007/9
N2 - Three Popeye domain-containing (Popdc 1-3) family-members are known in vertebrates. Their exact function is as yet unknown although involvement in cell adhesion has been suggested. We report herein sequencing of the rat Popdc 1-3 cDNAs that show high homology to other vertebrate orthologs and are expressed primarily in the heart and skeletal muscles. Popdc2 splice variants were identified, with Popdc2C showing a distinctive age-dependent decline. In isolated cardiomyocytes, Popdc genes were negatively regulated by serum, an effect that was reversed by EGFR-kinase inhibition, suggesting an EGFR-dependent modulation of Popdc gene expression.
AB - Three Popeye domain-containing (Popdc 1-3) family-members are known in vertebrates. Their exact function is as yet unknown although involvement in cell adhesion has been suggested. We report herein sequencing of the rat Popdc 1-3 cDNAs that show high homology to other vertebrate orthologs and are expressed primarily in the heart and skeletal muscles. Popdc2 splice variants were identified, with Popdc2C showing a distinctive age-dependent decline. In isolated cardiomyocytes, Popdc genes were negatively regulated by serum, an effect that was reversed by EGFR-kinase inhibition, suggesting an EGFR-dependent modulation of Popdc gene expression.
KW - Cardiomyocytes
KW - EGF receptor
KW - Heart
KW - Popeye domain containing (Popdc)
KW - Postnatal-regulation
KW - Rat
KW - Serum
UR - http://www.scopus.com/inward/record.url?scp=34548656541&partnerID=8YFLogxK
U2 - 10.1016/j.bbaexp.2007.06.001
DO - 10.1016/j.bbaexp.2007.06.001
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 17662479
AN - SCOPUS:34548656541
SN - 0167-4781
VL - 1769
SP - 586
EP - 592
JO - Biochimica et Biophysica Acta - Gene Structure and Expression
JF - Biochimica et Biophysica Acta - Gene Structure and Expression
IS - 9-10
ER -
