The Popdc gene family in the rat: Molecular cloning, characterization and expression analysis in the heart and cultured cardiomyocytes

Doris Parnes, Vered Jacoby, Avital Sharabi, Hadassa Schlesinger, Thomas Brand, Gania Kessler-Icekson

Research output: Contribution to journalArticlepeer-review

Abstract

Three Popeye domain-containing (Popdc 1-3) family-members are known in vertebrates. Their exact function is as yet unknown although involvement in cell adhesion has been suggested. We report herein sequencing of the rat Popdc 1-3 cDNAs that show high homology to other vertebrate orthologs and are expressed primarily in the heart and skeletal muscles. Popdc2 splice variants were identified, with Popdc2C showing a distinctive age-dependent decline. In isolated cardiomyocytes, Popdc genes were negatively regulated by serum, an effect that was reversed by EGFR-kinase inhibition, suggesting an EGFR-dependent modulation of Popdc gene expression.

Original languageEnglish
Pages (from-to)586-592
Number of pages7
JournalBiochimica et Biophysica Acta - Gene Structure and Expression
Volume1769
Issue number9-10
DOIs
StatePublished - Sep 2007
Externally publishedYes

Keywords

  • Cardiomyocytes
  • EGF receptor
  • Heart
  • Popeye domain containing (Popdc)
  • Postnatal-regulation
  • Rat
  • Serum

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