The pivotal role of deep vein thrombophlebitis in the development of acute disseminated staphylococcal disease in children.

A. Gorenstein*, E. Gross, S. Houri, G. Gewirts, S. Katz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Deep vein thrombophlebitis (DVT) and septic pulmonary emboli (PE) are rare in children. The association of DVT and acute disseminated staphylococcal disease (DSD) during childhood has not been previously reported. We report 3 children who developed a triad of DVT, septic PE, and acute osteomyelitis with Staphylococcus aureus cultured from blood and bone. One child succumbed, while 2 survived following prolonged, morbid hospitalizations. The rapid clinical deterioration observed in these patients might be caused by the aggressiveness of staphylococcal infection combined with an ongoing showering of septic emboli from the ileo-femoral DVT. We suggest that infected DVT with septic PE had a pivotal role in the development of DSD in these children. The presence of this triad should prompt aggressive treatment with the appropriate antibiotics, anticoagulation, surgical drainage, and assisted ventilation when indicated.

Original languageEnglish
Pages (from-to)E87
JournalPediatrics
Volume106
Issue number6
DOIs
StatePublished - Dec 2000
Externally publishedYes

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