TY - JOUR
T1 - The pharmacological effect on term neonates of analgesic drugs ingested through maternal milk
AU - Linder, Nehama
AU - German, Boris
AU - Bessant, David
AU - Sirota, Lea
AU - Zylber-Katz, Ester
AU - Martin, Oz
AU - Barzilai, Asher
PY - 1997
Y1 - 1997
N2 - Dipyrone and acetylsalicylic acid (ASA) are commonly used postpartum analgesic drugs. Because they are excreted in breast milk, whether they exert a pharmacological effect on infant neurobehaviour was investigated. For each drug, a doubleblind clinical trial involving 40 mothers and their normal full term infants was completed. One gram of analgesic drug or placebo was given to the mother, and infant activity was monitored for the remainder of that day. The influence of dipyrone on infants' behaviour could be clearly demonstrated: both the cumulative number of episodes of crying and their cumulative duration were significantly reduced in infants whose mothers received dipyrone. This effect diminished as the drug's level in breast milk declined. In contrast, ASA had no effect on infant behaviour.
AB - Dipyrone and acetylsalicylic acid (ASA) are commonly used postpartum analgesic drugs. Because they are excreted in breast milk, whether they exert a pharmacological effect on infant neurobehaviour was investigated. For each drug, a doubleblind clinical trial involving 40 mothers and their normal full term infants was completed. One gram of analgesic drug or placebo was given to the mother, and infant activity was monitored for the remainder of that day. The influence of dipyrone on infants' behaviour could be clearly demonstrated: both the cumulative number of episodes of crying and their cumulative duration were significantly reduced in infants whose mothers received dipyrone. This effect diminished as the drug's level in breast milk declined. In contrast, ASA had no effect on infant behaviour.
KW - Acetylsalicylic acid
KW - Breast milk
KW - Dipyrone
KW - Infant neurobehaviour
UR - http://www.scopus.com/inward/record.url?scp=0030785562&partnerID=8YFLogxK
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AN - SCOPUS:0030785562
SN - 1198-581X
VL - 4
SP - 112
EP - 114
JO - Journal of Population Therapeutics and Clinical Pharmacology
JF - Journal of Population Therapeutics and Clinical Pharmacology
IS - 3
ER -