The pharmacological effect on term neonates of analgesic drugs ingested through maternal milk

Nehama Linder*, Boris German, David Bessant, Lea Sirota, Ester Zylber-Katz, Oz Martin, Asher Barzilai

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Dipyrone and acetylsalicylic acid (ASA) are commonly used postpartum analgesic drugs. Because they are excreted in breast milk, whether they exert a pharmacological effect on infant neurobehaviour was investigated. For each drug, a doubleblind clinical trial involving 40 mothers and their normal full term infants was completed. One gram of analgesic drug or placebo was given to the mother, and infant activity was monitored for the remainder of that day. The influence of dipyrone on infants' behaviour could be clearly demonstrated: both the cumulative number of episodes of crying and their cumulative duration were significantly reduced in infants whose mothers received dipyrone. This effect diminished as the drug's level in breast milk declined. In contrast, ASA had no effect on infant behaviour.

Original languageEnglish
Pages (from-to)112-114
Number of pages3
JournalJournal of Population Therapeutics and Clinical Pharmacology
Volume4
Issue number3
StatePublished - 1997

Keywords

  • Acetylsalicylic acid
  • Breast milk
  • Dipyrone
  • Infant neurobehaviour

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