The pharmacokinetics of procainamide in normal subjects using a specific gas chromatographic assay.

K. J. Simons, R. H. Levy, R. E. Cutler, G. T. Christopher, A. Lindner

Research output: Contribution to journalArticlepeer-review

Abstract

Previous procainamide pharmacokinetic studies have involved the use of colorimetric and fluorimetric methods for the determination of drug concentrations in plasma and urine. However, recent evidence shows that N-acetyl procainamide, the major metabolite in humans, is hydrolyzed during these assay procedures. As a result, a specific gas chromatographic method has been developed for the determination of procainamide in biological fluids. Using this assay procedure, the pharmacokinetics of procainamide were studied in 7 normal subjects following intravenous administration of the drug. The values of half-life (2.08 +/- 0.52 hr), volume of distribution (4.3 +/- 0.6 1/Kg) and total body clearance (1344 +/- 238 ml/min) found in this study differed from those previously reported. These discrepancies could be understood in terms of differences in assay specificity.

Original languageEnglish
Pages (from-to)173-185
Number of pages13
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume11
Issue number2
StatePublished - Jun 1975

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