The peptide-binding strategy of the MHC class II I-A molecules

Boris Reizis, Miriam Eisenstein, Felix Mor, Irun R. Cohen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Despite the importance of murine major histocompatibility complex (MHC) class II I-A molecules for immunological research, the overall peptide- binding specificities of I-A and the homologous human HLA-DQ molecules remain unresolved. Here, Boris Reizis and colleagues review current evidence suggesting that DQ/I-A molecules bind peptides with a different hierarchy of anchor positions than has been found in the well-characterized DR/I-E proteins.

Original languageEnglish
Pages (from-to)212-216
Number of pages5
JournalImmunology Today
Issue number5
StatePublished - 1 May 1998
Externally publishedYes


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