TY - JOUR
T1 - The peptide-binding strategy of the MHC class II I-A molecules
AU - Reizis, Boris
AU - Eisenstein, Miriam
AU - Mor, Felix
AU - Cohen, Irun R.
N1 - Funding Information:
M.E. was supported by the Kimmelman Center for Macromolecular Assembly. I.R.C. is the incumbent of the Mauerberger Chair in Immunology and the Director of the Robert Koch-Minerva Center for Research in Autoimmune Diseases.
PY - 1998/5/1
Y1 - 1998/5/1
N2 - Despite the importance of murine major histocompatibility complex (MHC) class II I-A molecules for immunological research, the overall peptide- binding specificities of I-A and the homologous human HLA-DQ molecules remain unresolved. Here, Boris Reizis and colleagues review current evidence suggesting that DQ/I-A molecules bind peptides with a different hierarchy of anchor positions than has been found in the well-characterized DR/I-E proteins.
AB - Despite the importance of murine major histocompatibility complex (MHC) class II I-A molecules for immunological research, the overall peptide- binding specificities of I-A and the homologous human HLA-DQ molecules remain unresolved. Here, Boris Reizis and colleagues review current evidence suggesting that DQ/I-A molecules bind peptides with a different hierarchy of anchor positions than has been found in the well-characterized DR/I-E proteins.
UR - http://www.scopus.com/inward/record.url?scp=0031780202&partnerID=8YFLogxK
U2 - 10.1016/S0167-5699(97)01238-3
DO - 10.1016/S0167-5699(97)01238-3
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 9613038
AN - SCOPUS:0031780202
SN - 1471-4906
VL - 19
SP - 212
EP - 216
JO - Trends in Immunology
JF - Trends in Immunology
IS - 5
ER -