The penetration of ciprofloxacin into bronchial mucosa, lung parenchyma, and pleural tissue after intravenous administration

M. Dan*, K. Torossian, D. Weissberg, R. Kitzes

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

We have studied the concentrations of ciprofloxacin in serum, bronchial mucosa, lung parenchyma, and pleural tissue after a single intravenous dose of 200 mg in 20 patients subjected to lung surgery. The concentrations of ciprofloxacin in the tissues exceeded that in the serum by 3-fold to 7-fold: serum 0.6 μg·ml-1, bronchial mucosa 1.9 μg·g-1 lung parenchyma 3.4 μg·g-, and pleural tissue 1.7 μg·g-1. The achievable concentrations of ciprofloxacin in the tissues of the lower respiratory tract are above the MICs for most lung pathogens.

Original languageEnglish
Pages (from-to)101-102
Number of pages2
JournalEuropean Journal of Clinical Pharmacology
Volume44
Issue number1
DOIs
StatePublished - Jan 1993
Externally publishedYes

Keywords

  • Ciprofloxacin
  • bronchial mucosa
  • lung parenchyma
  • pleura
  • quinolones
  • tissue penetration

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