TY - JOUR
T1 - The Ped-APS registry
T2 - The antiphospholipid syndrome in childhood
AU - Avčin, Tadej
AU - Cimaz, R.
AU - Rozman, B.
AU - Cervera, Ricard
AU - Ravelli, Angelo
AU - Martini, Alberto
AU - Meroni, Pier Luigi
AU - Garay, Stella
AU - Sztajnbok, Flavio R.
AU - Silva, Clovis A.
AU - Campos, Lucia M.
AU - Saad-Magalhaes, Claudia
AU - de Oliveira, Sheila Knupp Feitosa
AU - Silverman, Earl D.
AU - Nielsen, Susan
AU - Pruunsild, Chris
AU - Dressler, Frank
AU - Berkun, Yackov
AU - Padeh, Shai
AU - Barash, Judith
AU - Uziel, Yosef
AU - Harel, Liora
AU - Mukamel, Masha
AU - Revel-Vilk, Shoshana
AU - Kenet, Gili
AU - Gattorno, Marco
AU - Rigante, Donato
AU - Zulian, Francesco
AU - Falcini, Fernanda
AU - Kuzmanovska, Dafina B.
AU - Susic, Gordana
AU - Buyukgebiz, Atilla
AU - Ozisik, Kanat
AU - Gozdasoglu, Sevgi
AU - Rodriguez, Vilmarie
AU - Butani, Lavjay
PY - 2009
Y1 - 2009
N2 - In recent years, antiphospholipid syndrome (APS) has been increasingly recognised in various paediatric autoimmune and nonautoimmune diseases, but the relatively low prevalence and heterogeneity of APS in childhood made it very difficult to study in a systematic way. The project of an international registry of paediatric patients with APS (the Ped-APS Registry) was initiated in 2004 to foster and conduct multicentre, controlled studies with large number of paediatric APS patients. The Ped-APS Registry is organised as a collaborative project of the European Forum on Antiphospholipid Antibodies and Juvenile Systemic Lupus Erythematosus Working Group of the Paediatric Rheumatology European Society. Currently, it documents a standardised clinical, laboratory and therapeutic data of 133 children with antiphospholipid antibodies (aPL)-related thrombosis from 14 countries. The priority projects for future research of the Ped-APS Registry include prospective enrolment of new patients with aPL-related thrombosis, assessment of differences between the paediatric and adult APS, evaluation of proinflammatory genotype as a risk factor for APS manifestations in childhood and evaluation of patients with isolated nonthrombotic aPL-related manifestations.
AB - In recent years, antiphospholipid syndrome (APS) has been increasingly recognised in various paediatric autoimmune and nonautoimmune diseases, but the relatively low prevalence and heterogeneity of APS in childhood made it very difficult to study in a systematic way. The project of an international registry of paediatric patients with APS (the Ped-APS Registry) was initiated in 2004 to foster and conduct multicentre, controlled studies with large number of paediatric APS patients. The Ped-APS Registry is organised as a collaborative project of the European Forum on Antiphospholipid Antibodies and Juvenile Systemic Lupus Erythematosus Working Group of the Paediatric Rheumatology European Society. Currently, it documents a standardised clinical, laboratory and therapeutic data of 133 children with antiphospholipid antibodies (aPL)-related thrombosis from 14 countries. The priority projects for future research of the Ped-APS Registry include prospective enrolment of new patients with aPL-related thrombosis, assessment of differences between the paediatric and adult APS, evaluation of proinflammatory genotype as a risk factor for APS manifestations in childhood and evaluation of patients with isolated nonthrombotic aPL-related manifestations.
KW - Antiphospholipid antibodies
KW - Antiphospholipid syndrome
KW - Paediatrics
UR - http://www.scopus.com/inward/record.url?scp=68949191174&partnerID=8YFLogxK
U2 - 10.1177/0961203309106917
DO - 10.1177/0961203309106917
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C2 - 19671789
AN - SCOPUS:68949191174
SN - 0961-2033
VL - 18
SP - 894
EP - 899
JO - Lupus
JF - Lupus
IS - 10
ER -