The pattern and evolution of yeast promoter bendability

Itay Tirosh, Judith Berman, Naama Barkai

Research output: Contribution to journalShort surveypeer-review

Abstract

In Saccharomyces cerevisiae, transcription factor binding sites are found preferentially ∼100-200 bp upstream of the start codon. Here, we show that this region is associated with rigid DNA in promoters lacking a TATA box, but not in TATA-containing promoters. The association of rigid DNA with transcription factor binding sites is conserved in TATA-less promoters from 11 yeast species, whereas the position of the rigid DNA varies substantially among species. Rigid DNA could influence nucleosome positioning and assist in the assembly of the transcriptional machinery at TATA-less promoters.

Original languageEnglish
Pages (from-to)318-321
Number of pages4
JournalTrends in Genetics
Volume23
Issue number7
DOIs
StatePublished - Jul 2007
Externally publishedYes

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