The patient with recurrent (sub) obstruction due to Crohn's disease

Adi Lahat, Yehuda Chowers

Research output: Contribution to journalArticlepeer-review

Abstract

Stricturing Crohn's disease (CD) occurs in 12-54% of the CD patient population and is associated with significant morbidity and impaired quality of life. The detailed pathophysiology of stricture formation has not been fully elucidated, but is primarily associated with luminal narrowing secondary to inflammation and the fibrosis that ensues during mucosal healing. The diagnosis of stricturing disease is based on clinical signs and symptoms along with imaging modalities. The advantages and shortcomings of each imaging modality are discussed. Treatment options are based on the differentiation between inflammatory versus fibrous-predominant strictures; whereas the former can potentially be managed with conservative medical treatment, the latter necessitates a mechanical solution through endoscopy or surgery. Indications, contra-indications and success rates of the different therapeutic approaches are discussed.

Original languageEnglish
Pages (from-to)427-444
Number of pages18
JournalBailliere's Best Practice and Research in Clinical Gastroenterology
Volume21
Issue number3
DOIs
StatePublished - Jun 2007
Externally publishedYes

Keywords

  • balloon dilation
  • Crohn's disease
  • fibrosis
  • inflammation
  • strictureplasty
  • strictures
  • therapy

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