The pathophysiology and clinical presentation of cerebral amyloid angiopathy

Eitan Auriel, Steven Mark Greenberg*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Cerebral amyloid angiopathy (CAA) is defined as the deposition of amyloid ß peptide within leptomeningial and cortical vessels, likely reflecting an imbalance between Aß production and clearance. Amyloid buildup triggers a series of destructive alterations in the cerebral vascular architecture, leading to a spectrum of neurological events including lobar intracerebral hemorrhage, brain ischemia and cognitive decline. Although traditionally diagnosed pathologically, neuroimaging has taken a central role in defining CAA. This review will discuss the pathological, clinical and radiological aspects of CAA.

Original languageEnglish
Pages (from-to)343-350
Number of pages8
JournalCurrent Atherosclerosis Reports
Issue number4
StatePublished - Aug 2012
Externally publishedYes


  • Cerebral amyloid angiopathy
  • Intracerebral hemorrhage
  • Stroke
  • Vascular dementia


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