The pathogenic 16/6 idiotype in patients with silica associated systemic lupus erythematosus (SLE) and uranium miners with increased risk for development of SLE

Karsten Conrad, Yair Levy, Miri Blank, Jürgen Mehlhorn, Karl Heinz Frank, Beate Roch, Yehuda Shoenfeld

Research output: Contribution to journalArticlepeer-review

Abstract

Objective. To investigate the prevalence of the 16/6 idiotype (16/6 Id), a major cross reactive idiotype of anti-DNA antibodies involved in the pathogenesis of experimental lupus, in subjects with an exogenous risk for the development of systemic lupus erythematosus (SLE). Methods. The titer of 16/6 Id was determined by ELISA in sera of uranium miners exposed to heavy quartz dust: 15 developed definite and 12 probable SLE, 34 had clinical symptoms, and 27 had only serological signs (medium to high titer anti-dsDNA antibodies) of possible connective tissue disease (CTD) development. Results. The prevalence of 16/6 Id was higher in all groups compared to healthy blood donors. It was 18.5% in miners with SLE (definite and probable) and 22.2- 26.5% in miners with clinical and/or serological signs for developing CTD. All 16/6 Id positive miners were positive for anti-dsDNA antibodies and other autoantibodies associated with CTD. The prevalence of 16/6 Id in anti-dsDNA positive miners correlated slightly with CTD/SLE symptoms: 55.6% in patients with SLE, 47.4% in miners with possible CTD/SLE, and 22.2% in miners without CTD symptoms. Further, at short term follow-up, disease progressed in 2 miners of the 16/6 Id positive, but not in 16/6 Id negative miners. Conclusion. The detection of 16/6 Id in miners exposed to quartz dust may indicate a higher risk for development of SLE, warranting further studies of the role of 16/6 Id in the development of SLE in a cohort with the same sex, ethnicity, geographic region, and occupation.

Original languageEnglish
Pages (from-to)660-666
Number of pages7
JournalJournal of Rheumatology
Volume25
Issue number4
StatePublished - Apr 1998
Externally publishedYes

Keywords

  • Anti-DNA antibodies
  • Idiotypes
  • SLE
  • Silica
  • Xenobiotically induced lupus

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