The participation of trimethylammonium in the mouse erythrocyte epitope recognized by monoclonal autoantibodies

Dan Serban*, Jaqueline M. Pages, Alain E. Bussard, Isaac P. Witz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Monoclonal IgM anti-erythrocyte autoantibody produced by a NZB-derived hybridoma has been found to react with trimethylammonium-containing compounds. Such compounds are able to prevent the lysis of bromelain-treated mouse erythrocytes (BrMRBC) by those autoantibodies. Using a column of insolubilized betaine hydrazide (BH) the monoclonal anti-erythrocyte antibody has been specifically retained. Elution of this antibody was accomplished by 0.15 M choline (Ch).

Original languageEnglish
Pages (from-to)315-319
Number of pages5
JournalImmunology Letters
Volume3
Issue number5
DOIs
StatePublished - Nov 1981

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