The outcome of pseudotumor cerebri induced by tetracycline therapy

Anat Kesler*, Y. Goldhammer, A. Hadayer, P. Pianka

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objective - To demonstrate the association between tetracycline treatment and pseudotumor cerebri (PTC). Methods - Consecutive patients from two neuro-ophthalmic referral centers, who developed PTC syndrome post-treatment with tetracycline, were enrolled and followed for a minimum of 2 years after cessation of tetracycline. Results - A total of 243 consecutive patients were diagnosed with PTC; 18 had concurrent history of tetracycline treatment; a third experienced a limited course of illness with no relapses; 12 had a variable course with a prolonged relapsing illness. Mean duration of tetracycline treatment prior to diagnosis was 2.73 months. Conclusions - Tetracycline, and especially minocycline, is currently considered a cause or a precipitating factor for PTC. Although there is little information on the natural course of tetracycline induced PTC, the present cases demonstrate that drug withdrawal is curative only in some patients.

Original languageEnglish
Pages (from-to)408-411
Number of pages4
JournalActa Neurologica Scandinavica
Issue number6
StatePublished - Dec 2004
Externally publishedYes


  • Idiopathic intracranial hypertension
  • Pseudotumor cerebri
  • Tetracycline


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