The OMERACT MRI in enthesitis initiative: Definitions of key pathologies, suggested MRI sequences, and a novel heel enthesitis scoring system

Ashish J. Mathew; Simon Krabbe; Iris Eshed; Frédérique Gandjbakhch; Paul Bird; Susanne J. Pedersen; Maria S. Stoenoiu; Violaine Foltz; Daniel Glinatsi; Robert G. Lambert; Kay Geert A. Hermann; Walter P. Maksymowych; Ida K. Haugen; Jacob L. Jaremko; René P. Poggenborg; Joel Paschke; Jean Denis Laredo; Philippe Carron; Philip G. Conaghan; Mikkel Østergaard

doi:10.3899/jrheum.181093

The OMERACT MRI in enthesitis initiative: Definitions of key pathologies, suggested MRI sequences, and a novel heel enthesitis scoring system

Ashish J. Mathew, Simon Krabbe, Iris Eshed, Frédérique Gandjbakhch, Paul Bird, Susanne J. Pedersen, Maria S. Stoenoiu, Violaine Foltz, Daniel Glinatsi, Robert G. Lambert, Kay Geert A. Hermann, Walter P. Maksymowych, Ida K. Haugen, Jacob L. Jaremko, René P. Poggenborg, Joel Paschke, Jean Denis Laredo, Philippe Carron, Philip G. Conaghan, Mikkel Østergaard^*

^*Corresponding author for this work

Diagnostic Imaging

Research output: Contribution to journal › Review article › peer-review

47 Scopus citations

Abstract

Objective. To develop and validate an enthesitis magnetic resonance imaging (MRI) scoring system for spondyloarthritis/psoriatic arthritis, using the heel as model. Methods. Consensus definitions of key pathologies and 3 heel enthesitis multireader scoring exercises were done, separated by discussion, training, and calibration. Results. Definitions for bone and soft tissue pathologies were agreed. In the final exercise, median pairwise single-measures intraclass correlation coefficients (ICC; patient-level) for entheseal inflammation status/change scores were 0.83/0.82 for all readers. For radiologists and selected rheumatologists, ICC were 0.91/0.84 and quadratic-weighted κ (lesion-level) 0.57-0.91/0.45-0.81. Conclusion. The proposed definitions and Heel Enthesitis Scoring System (HEMRIS) are reliable among trained readers and promising for clinical trials.

Original language	English
Pages (from-to)	1232-1238
Number of pages	7
Journal	Journal of Rheumatology
Volume	46
Issue number	9
DOIs	https://doi.org/10.3899/jrheum.181093
State	Published - 1 Sep 2019

Funding

Funders	Funder number
Canadian Research and Education
Leeds Biomedical Research Centre
National Health Service
National Institute for Health Research

Keywords

Enthesopathy
Magnetic resonance imaging
Omeract
Psoriatic arthritis
Spondyloarthropathy

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10.3899/jrheum.181093

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Mathew, A. J., Krabbe, S., Eshed, I., Gandjbakhch, F., Bird, P., Pedersen, S. J., Stoenoiu, M. S., Foltz, V., Glinatsi, D., Lambert, R. G., Hermann, K. G. A., Maksymowych, W. P., Haugen, I. K., Jaremko, J. L., Poggenborg, R. P., Paschke, J., Laredo, J. D., Carron, P., Conaghan, P. G., & Østergaard, M. (2019). The OMERACT MRI in enthesitis initiative: Definitions of key pathologies, suggested MRI sequences, and a novel heel enthesitis scoring system. Journal of Rheumatology, 46(9), 1232-1238. https://doi.org/10.3899/jrheum.181093

@article{a0b8a1f7062b4f1489f06f572e347054,

title = "The OMERACT MRI in enthesitis initiative: Definitions of key pathologies, suggested MRI sequences, and a novel heel enthesitis scoring system",

abstract = "Objective. To develop and validate an enthesitis magnetic resonance imaging (MRI) scoring system for spondyloarthritis/psoriatic arthritis, using the heel as model. Methods. Consensus definitions of key pathologies and 3 heel enthesitis multireader scoring exercises were done, separated by discussion, training, and calibration. Results. Definitions for bone and soft tissue pathologies were agreed. In the final exercise, median pairwise single-measures intraclass correlation coefficients (ICC; patient-level) for entheseal inflammation status/change scores were 0.83/0.82 for all readers. For radiologists and selected rheumatologists, ICC were 0.91/0.84 and quadratic-weighted κ (lesion-level) 0.57-0.91/0.45-0.81. Conclusion. The proposed definitions and Heel Enthesitis Scoring System (HEMRIS) are reliable among trained readers and promising for clinical trials.",

keywords = "Enthesopathy, Magnetic resonance imaging, Omeract, Psoriatic arthritis, Spondyloarthropathy",

author = "Mathew, {Ashish J.} and Simon Krabbe and Iris Eshed and Fr{\'e}d{\'e}rique Gandjbakhch and Paul Bird and Pedersen, {Susanne J.} and Stoenoiu, {Maria S.} and Violaine Foltz and Daniel Glinatsi and Lambert, {Robert G.} and Hermann, {Kay Geert A.} and Maksymowych, {Walter P.} and Haugen, {Ida K.} and Jaremko, {Jacob L.} and Poggenborg, {Ren{\'e} P.} and Joel Paschke and Laredo, {Jean Denis} and Philippe Carron and Conaghan, {Philip G.} and Mikkel {\O}stergaard",

year = "2019",

month = sep,

day = "1",

doi = "10.3899/jrheum.181093",

language = "אנגלית",

volume = "46",

pages = "1232--1238",

journal = "Journal of Rheumatology",

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Mathew, AJ, Krabbe, S, Eshed, I, Gandjbakhch, F, Bird, P, Pedersen, SJ, Stoenoiu, MS, Foltz, V, Glinatsi, D, Lambert, RG, Hermann, KGA, Maksymowych, WP, Haugen, IK, Jaremko, JL, Poggenborg, RP, Paschke, J, Laredo, JD, Carron, P, Conaghan, PG & Østergaard, M 2019, 'The OMERACT MRI in enthesitis initiative: Definitions of key pathologies, suggested MRI sequences, and a novel heel enthesitis scoring system', Journal of Rheumatology, vol. 46, no. 9, pp. 1232-1238. https://doi.org/10.3899/jrheum.181093

TY - JOUR

T1 - The OMERACT MRI in enthesitis initiative

T2 - Definitions of key pathologies, suggested MRI sequences, and a novel heel enthesitis scoring system

AU - Mathew, Ashish J.

AU - Krabbe, Simon

AU - Eshed, Iris

AU - Gandjbakhch, Frédérique

AU - Bird, Paul

AU - Pedersen, Susanne J.

AU - Stoenoiu, Maria S.

AU - Foltz, Violaine

AU - Glinatsi, Daniel

AU - Lambert, Robert G.

AU - Hermann, Kay Geert A.

AU - Maksymowych, Walter P.

AU - Haugen, Ida K.

AU - Jaremko, Jacob L.

AU - Poggenborg, René P.

AU - Paschke, Joel

AU - Laredo, Jean Denis

AU - Carron, Philippe

AU - Conaghan, Philip G.

AU - Østergaard, Mikkel

PY - 2019/9/1

Y1 - 2019/9/1

N2 - Objective. To develop and validate an enthesitis magnetic resonance imaging (MRI) scoring system for spondyloarthritis/psoriatic arthritis, using the heel as model. Methods. Consensus definitions of key pathologies and 3 heel enthesitis multireader scoring exercises were done, separated by discussion, training, and calibration. Results. Definitions for bone and soft tissue pathologies were agreed. In the final exercise, median pairwise single-measures intraclass correlation coefficients (ICC; patient-level) for entheseal inflammation status/change scores were 0.83/0.82 for all readers. For radiologists and selected rheumatologists, ICC were 0.91/0.84 and quadratic-weighted κ (lesion-level) 0.57-0.91/0.45-0.81. Conclusion. The proposed definitions and Heel Enthesitis Scoring System (HEMRIS) are reliable among trained readers and promising for clinical trials.

AB - Objective. To develop and validate an enthesitis magnetic resonance imaging (MRI) scoring system for spondyloarthritis/psoriatic arthritis, using the heel as model. Methods. Consensus definitions of key pathologies and 3 heel enthesitis multireader scoring exercises were done, separated by discussion, training, and calibration. Results. Definitions for bone and soft tissue pathologies were agreed. In the final exercise, median pairwise single-measures intraclass correlation coefficients (ICC; patient-level) for entheseal inflammation status/change scores were 0.83/0.82 for all readers. For radiologists and selected rheumatologists, ICC were 0.91/0.84 and quadratic-weighted κ (lesion-level) 0.57-0.91/0.45-0.81. Conclusion. The proposed definitions and Heel Enthesitis Scoring System (HEMRIS) are reliable among trained readers and promising for clinical trials.

KW - Enthesopathy

KW - Magnetic resonance imaging

KW - Omeract

KW - Psoriatic arthritis

KW - Spondyloarthropathy

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U2 - 10.3899/jrheum.181093

DO - 10.3899/jrheum.181093

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C2 - 30709961

AN - SCOPUS:85071787224

SN - 0315-162X

VL - 46

SP - 1232

EP - 1238

JO - Journal of Rheumatology

JF - Journal of Rheumatology

IS - 9

ER -

The OMERACT MRI in enthesitis initiative: Definitions of key pathologies, suggested MRI sequences, and a novel heel enthesitis scoring system

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