The Nucleolus as a Proteostasis Regulator

Fatima Amer-Sarsour, Avraham Ashkenazi*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review


Protein misfolding is linked to disease, so how do mammalian cells cope with the burden of misfolded proteins in the nucleus? A recent study in Science (Frottin et al., 2019) demonstrated that on proteotoxic stress, the nucleolus could store some misfolded proteins for refolding or degradation.

Original languageEnglish
Pages (from-to)849-851
Number of pages3
JournalTrends in Cell Biology
Issue number11
StatePublished - Nov 2019


  • chaperones
  • neurodegenerative diseases
  • nucleus
  • protein quality control


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