TY - JOUR
T1 - The Nucleolus as a Proteostasis Regulator
AU - Amer-Sarsour, Fatima
AU - Ashkenazi, Avraham
N1 - Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/11
Y1 - 2019/11
N2 - Protein misfolding is linked to disease, so how do mammalian cells cope with the burden of misfolded proteins in the nucleus? A recent study in Science (Frottin et al., 2019) demonstrated that on proteotoxic stress, the nucleolus could store some misfolded proteins for refolding or degradation.
AB - Protein misfolding is linked to disease, so how do mammalian cells cope with the burden of misfolded proteins in the nucleus? A recent study in Science (Frottin et al., 2019) demonstrated that on proteotoxic stress, the nucleolus could store some misfolded proteins for refolding or degradation.
KW - chaperones
KW - neurodegenerative diseases
KW - nucleus
KW - protein quality control
UR - http://www.scopus.com/inward/record.url?scp=85071288883&partnerID=8YFLogxK
U2 - 10.1016/j.tcb.2019.08.002
DO - 10.1016/j.tcb.2019.08.002
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AN - SCOPUS:85071288883
SN - 0962-8924
VL - 29
SP - 849
EP - 851
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 11
ER -