@article{39e7ea4e68fd44d289c13cfa2dbc9bf5,
title = "The NRF2-related interactome and regulome contain multifunctional proteins and fine-tuned autoregulatory loops",
abstract = "NRF2 is a well-known, master transcription factor (TF) of oxidative and xenobiotic stress responses. Recent studies uncovered an even wider regulatory role of NRF2 influencing carcinogenesis, inflammation and neurodegeneration. Prompted by these advances here we present a systems-level resource for NRF2 interactome and regulome that includes 289 protein-protein, 7469 TF-DNA and 85 miRNA interactions. As systems-level examples of NRF2-related signaling we identified regulatory loops of NRF2 interacting proteins (e.g., JNK1 and CBP) and a fine-tuned regulatory system, where 35 TFs regulated by NRF2 influence 63 miRNAs that down-regulate NRF2. The presented network and the uncovered regulatory loops may facilitate the development of efficient, NRF2-based therapeutic agents.",
keywords = "Double-edged sword, Interaction prediction, NRF2, Protein-protein interaction, Regulatory loops, Signaling network",
author = "Di{\'a}na Papp and Katalin Lenti and Dezso M{\'o}dos and D{\'a}vid Fazekas and Zolt{\'a}n D{\'u}l and D{\'e}nes T{\"u}rei and L{\'a}szl{\'o} F{\"o}ldv{\'a}ri-Nagy and Ruth Nussinov and P{\'e}ter Csermely and Tam{\'a}s Korcsm{\'a}ros",
note = "Funding Information: We thank the anonymous reviewers for their advice and G. Szuromi for technical help. This project has been funded in whole or in part with Federal funds from the National Cancer Institute, National Institutes of Health, under contract number HHSN261200800001E, by the EU-ESF grant TAMOP 4.2.1./B-09/1/KMR-2010-0003 and TAMOP-4.2.2/B-10/1-2010-0013, the Hungarian Scientific Research Fund (OTKA K83314), the Hungarian Research and Technology Office (5LET-08-2-2009-0041) and by a residence at the Rockefeller Foundation Bellagio Center for PC. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. This research was supported (in part) by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research. ",
year = "2012",
month = jun,
day = "21",
doi = "10.1016/j.febslet.2012.05.016",
language = "אנגלית",
volume = "586",
pages = "1795--1802",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Wiley-Blackwell",
number = "13",
}