The NOTCH pathway in β-cell growth and differentiation

Yael Bar, Shimon Efrat*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Beta-cell replacement represents the optimal therapy for type 1 diabetes. Efforts to manipulate β-cell proliferation and differentiation could be advanced by a better understanding of the normal pathways regulating β-cell development and renewal. NOTCH signaling is a highly conserved pathway which plays a central role in pancreas development. Cell-lineage tracing has revealed the reactivation of the NOTCH pathway in adult human β cells cultured under conditions which induce cell proliferation and dedifferentiation. Inhibition of NOTCH signaling in dedifferentiated cells following ex vivo expansion has been shown to promote restoration of the β-cell phenotype. This approach may increase the availability of functional β cells for transplantation.

Original languageEnglish
Title of host publicationVitamins and Hormones
PublisherAcademic Press Inc.
Number of pages15
StatePublished - 2014

Publication series

NameVitamins and Hormones
ISSN (Print)0083-6729


FundersFunder number
Juvenile Diabetes Research Foundation International
Israel Science Foundation


    • Cell transplantation
    • Diabetes
    • HES1
    • Insulin
    • Islet cell proliferation
    • Pancreas development
    • Redifferentiation


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