@inbook{4468a81933c049d2a8eef9a58aa78e38,
title = "The NOTCH pathway in β-cell growth and differentiation",
abstract = "Beta-cell replacement represents the optimal therapy for type 1 diabetes. Efforts to manipulate β-cell proliferation and differentiation could be advanced by a better understanding of the normal pathways regulating β-cell development and renewal. NOTCH signaling is a highly conserved pathway which plays a central role in pancreas development. Cell-lineage tracing has revealed the reactivation of the NOTCH pathway in adult human β cells cultured under conditions which induce cell proliferation and dedifferentiation. Inhibition of NOTCH signaling in dedifferentiated cells following ex vivo expansion has been shown to promote restoration of the β-cell phenotype. This approach may increase the availability of functional β cells for transplantation.",
keywords = "Cell transplantation, Diabetes, HES1, Insulin, Islet cell proliferation, Pancreas development, Redifferentiation",
author = "Yael Bar and Shimon Efrat",
note = "Funding Information: This work was supported by the Israel Science Foundation and the Juvenile Diabetes Research Foundation.",
year = "2014",
doi = "10.1016/B978-0-12-800174-5.00015-6",
language = "אנגלית",
series = "Vitamins and Hormones",
publisher = "Academic Press Inc.",
pages = "391--405",
booktitle = "Vitamins and Hormones",
address = "ארצות הברית",
}
